摘要
目的 探讨替罗非班联合大黄䗪虫丸治疗老年急性缺血性脑卒中(AIS)患者的疗效及对血清人帕金森蛋白(PARK7)、Sestrin2水平的影响。方法 选取2020-08—2022-03山东省文登整骨医院收治的老年AIS患者116例,随机分为观察组(n=58)和对照组(n=58),对照组采用替罗非班治疗,观察组在对照组的基础上联合大黄䗪虫丸治疗,从入院当日开始,干预为期4周。比较2组患者入院当日及治疗4周后治疗有效率、血流平均流速(TMV)、收缩期峰值流速(PSV)、阻力指数(RI),血清同型半胱氨酸酶(Hcy)、PARK7、2Sestrin水平,以及不良反应发生率。结果 治疗4周后观察组血清PARK7、Sestrin2、Hcy水平、RI[分别为(14.47±2.74)μg/L、(11.01±1.64)μg/L、(11.08±1.69)μmol/L、0.62±0.18]均低于对照组[分别为(19.15±2.68)μg/L、(14.37±1.67)μg/L、(16.60±2.73)μmol/L、0.75±0.15](P<0.05),观察组血流TMV[(46.37±6.17)cm/s]、PSV[(77.16±8.41)cm/s]水平均高于对照组[分别为(37.72±5.16)cm/s、(63.72±7.21)cm/s](P<0.05)。2组有效率分别为91.38%、74.14%,观察组治疗有效率高于对照组(P<0.05)。2组不良反应发生率分别为24.14%、8.62%,观察组不良反应发生率低于对照组(P<0.05)。结论 替罗非班联合大黄䗪虫丸能够有效改善AIS患者神经功能及脑部血流灌注情况,降低血清PARK7、Sestrin2水平,提升有效率,减少并发症,加快康复进程。
Objective To investigate the effect of tirofiban combined with Dahuang Zhechong pill on the levels of serum human Parkinson’s protein(PARK7)and Sestrin2 in the elderly patients with acute ischemic stroke(AIS).Methods From August 2020 to March 2022,116 elderly patients with AIS caused by acute ischemic stroke in Shandong Wendeng Osteopathic Hospital were selected.They were divided into the observation group(n=58)and the control group(n=58)according to different treatment methods.The control group was treated with tirofiban.The observation group was treated with Dahuang Zhechong pill on the basis of the control group.The intervention lasted for 4 weeks.The effective rate,mean flow velocity(TMV),peak systolic flow velocity(PSV),resistance index(RI),serum homocysteine(Hcy),PARK7,Sestrin2 and the incidence of adverse reactions were compared on the day of admission and 4 weeks after treatment.Results After 4 weeks of treatment,the serum levels of PARK7,Sestrin2,Hcy,and RI in the observation group((14.47±2.74)μg/L,(11.01±1.64)μg/L,(11.08±1.69)μmol/L and 0.62±0.18,respectively)were lower than those in the control group((19.15±2.68)μg/L,(14.37±1.67)μg/L,(16.60±2.73)μmol/L,0.75±0.15,respectively,P<0.05),the levels of blood flow TMV((46.37±6.17)cm/s)and PSV((77.16±8.41)cm/s)in the observation group were higher than those in the control group((37.72±5.16)cm/s,(63.72±7.21)cm/s,respectively,P<0.05).The effective rate of the two groups was 91.38%and 74.14%,respectively,the observation group was higher than the control group(P<0.05).The incidence of adverse reactions in the two groups was 24.14%and 8.62%,respectively,the observation group was lower than the control group(P<0.05).Conclusion The combination of tirofiban and Dahuang Zhechong pill can effectively improve the neurological function and cerebral blood flow perfusion of AIS patients,reduce the levels of serum PARK7 and Sestrin2,improve the treatment efficiency,reduce the occurrence of complications,and accelerate the recovery process.
作者
王德文
唐丽
于慧静
WANG Dewen;TANG Li;YU Huijing(Shandong Wendeng Osteopathic Hospital,Weihai 264400,China)
出处
《中国实用神经疾病杂志》
2024年第4期483-487,共5页
Chinese Journal of Practical Nervous Diseases
基金
威海市中医药科技项目面上项目(编号:2021N-15)。
