摘要
目的探讨中老年人5 a内主观认知下降(SCD)进展的影响因素。方法选取2011—2018年中国健康与退休纵向研究(CHARLS)数据库中SCD人群为研究对象,根据5 a随访后的自身前后认知评分改变评估分为SCD进展组和SCD非进展组,使用1∶1倾向性评分匹配方法控制一般资料,匹配后的人群采用Logistic回归模型,分析SCD进展的影响因素。结果基线检查时报告3864例SCD中,258例SCD进展(6.68%);匹配前2组性别、BMI、教育水平、吸烟、CES-D 10得分、就餐模式、舒张压、平衡测试、握力、CRP水平差异有统计学意义;将匹配后2组比较中P<0.1的变量纳入Logistic回归分析,纳入CES-D 10得分(χ^(2)=2.494,P=0.01)、舒张压(Z=11.946,P=0.10)、平衡测试(Z=3.853,P=0.06)、CRP水平(Z=-1.646,P=0.10),结果显示CES-D 10得分(P=0.01,OR=1.092,95%CI:1.019~1.171)以及平衡测试(P=0.03,OR=0.643,95%CI:0.427~0.967)可能是SCD人群5 a后进展的危险因素。结论更高的CES-D 10得分及不能完成平衡测试对SCD人群短期发生认知障碍进展有不利影响。
Objective To investigate the risk factors for the progression of subjective cognitive decline within 5 years among elderly people.Methods Based on changes in cognitive scores after a 5-year follow-up,we classified individuals with subjective cognitive decline(SCD)from the 2011-2018 China Health and Retirement Longitudinal Study(CHARLS)as either SCD progression or non-progression groups.We employed 1∶1 propensity score matching to adjust for overall data,and used Logistic regression model to examine the factors associated with SCD progression in the matched sample.Results Of the population reporting subjective cognitive decline(SCD)at baseline(n=3864),258 exhibited SCD progression(6.68%).Prior to matching,significant differences were observed between the two groups in variables gender,body mass index(BMI),education level,smoking,CES-D 10 score,dining mode,diastolic blood pressure,balance test,grip strength,and CRP level.After matching,variables with P<0.1 in the comparison between the two groups were included in Logistic regression analysis,including CES-D 10 score(χ^(2)=2.494,P=0.01),diastolic blood pressure(Z=11.946,P=0.10),balance test(Z=3.853,P=0.06),and CRP level(Z=-1.646,P=0.10),which indicate that both the CES-D 10 score(P=0.01,OR=1.092,95%CI:1.019-1.171)and balance test(P=0.03,OR=0.643,95%CI:0.427-0.967)may serve as significant risk factors for the progression of subjective cognitive decline over a follow-up period of 5 years in this population.Conclusion Higher CES-D 10 scores and inability to complete balance tests are significantly associated with increased risk of short-term progression of cognitive impairment in the SCD population.
作者
成美怡
刘洲
周海红
CHENG Meiyi;LIU Zhou;ZHOU Haihong(Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)
出处
《中国实用神经疾病杂志》
2024年第4期397-402,共6页
Chinese Journal of Practical Nervous Diseases
基金
国家自然科学基金资助项目(编号:82071475)。
关键词
主观认知下降
认知障碍
中国健康长寿纵向调查
倾向评分匹配
平衡测试
影响因素
Subjective cognitive decline
Cognitive impairment
Chinese Longitudinal Healthy Longevity Survey
Propensity score matching
Balance test
Influencing factor
