摘要
目的 分析湖州市疑似预防接种异常反应(AEFI)的监测资料,比较DTaP-IPV/Hib、 PPV23、DTaP、MR、MMR、VarV、JE-L、MPV-A、DT 9种疫苗的AEFI报告发生率,探讨AEFI发生风险的影响因素,为AEFI监测处置工作决策提供参考。方法 收集湖州市AEFI监测管理系统中2015—2019年9种疫苗AEFI个案资料,描述性方法分析AEFI发生情况,二元Logistic回归模型分析AEFI发生风险的影响因素。结果 9种疫苗AEFI累计报告发生率为58.36/10万,DTaP-IPV/Hib疫苗AEFI报告发生率最高(158.21/10万)。Logistic回归分析结果显示,接种MPV-A疫苗(OR=3.298,95%CI:1.224~8.886,P=0.018)局部红肿发生风险较高;女性(OR=1.36,95%CI:1.046~1.769,P=0.022)、1~4岁(OR=2.885,95%CI:1.011~8.232,P=0.048)、接种部位为右上臂(OR=3.888,95%CI:1.018~14.853,P=0.047)局部硬结发生风险较高。接种MPV-A疫苗、<1岁、接种第1剂次后至出现AEFI时间间隔最短,中位数分别为5.750(3.000,11.978)、7.18(4.000,23.130)、8.17(4.32,24.00)小时。不同疫苗、年龄、剂次出现AEFI的时间,差异均有统计学意义(均P<0.001)。结论 疫苗不良反应发生受到年龄、性别、接种部位等因素影响,应采用主动监测和被动监测相结合的方式及时发现不良反应并处置,以保障预防接种安全。
Objective Analyze the adverse events following immunization(AEFI)data in Huzhou City and compare the AEFI incidence rate of DTaP-IPV/Hib、PPV23、DTaP、MR、MMR、VarV、JE-L、MPV-A、DT vaccines to explore the influencing factors of AEFI risk,in order to provide reference basis for further AEFI monitoring and vaccination work.Methods Data on AEFI for nine vaccines administered between 2015 and 2019 in the AEFI surveillance management system in Huzhou City were collected.Descriptive methods were used to analyze the occurrence of AEFI,and binary logistic regression models were used to identify factors influencing the risk of AEFI.Results The cumulative incidence of AEFI for the nine vaccines was 58.36 per 100,000.The highest incidence of AEFI was reported for the DTaP-IPV/Hib vaccine at 158.21 per 100,000.The multifactorial logistic regression analysis revealed that the risk of local erythema was higher with MPV-A vaccination(OR=3.298,95%CI:1.224-8.886,P=0.018).The risk of local induration was higher in females(OR=1.36,95%CI:1.046-1.769,P=0.022),those aged 1 to 4 years(OR=2.885,95%CI:1.011-8.232,P=0.048),and those with injections in the right upper arm(OR=3.888,95%CI:1.018-14.853,P=0.047).The time intervals between vaccination with MPV-A and the appearance of AEFI were as follows:5.750(3.000,11.978)hours for those vaccinated at less than 1 year of age,7.18(4.000,23.130)hours for those vaccinated after the 1st dose,and 8.17(4.32,24.00)hours for those vaccinated after subsequent doses.The shortest time intervals between vaccination with MPV-A,<1 year of age,and after the 1st dose of vaccination to the appearance of AEFI were 5.750(3.000,11.978),7.18(4.000,23.130),and 8.17(4.32,24.00)hours,respectively.The differences in the time to AEFI by vaccine,age,and dose were statistically significant(all P<0.001).Conclusions Adverse reactions to vaccination can be influenced by various factors,such as age,gender,and vaccination site.To ensure the safety of vaccination,it is recommended to use a combination of active and pa
作者
张超
沈建勇
罗小福
徐秦儿
韩利萍
ZHANG Chao;SHEN Jianyong;LUO Xiaofu;XU Qiner;HAN Liping(Department of Immunization Planning,Huzhou Center for Disease Control and Prevention,Huzhou 313000,China)
出处
《健康研究》
CAS
2024年第1期80-85,共6页
Health Research
基金
湖州市科技计划项目(2020GY37)
湖州市疾病预防控制中心急性传染病学重点学科(ZDXK202202)。
关键词
疫苗
预防接种
疑似预防接种异常反应
影响因素
vaccine
immunization
adverse events following immunization
influencing factor
