摘要
目的探讨醒神解郁汤联合针刺对老年卒中后抑郁患者的疗效及对血清5-羟色胺(5-HT)、去甲肾上腺素(NE)的影响。方法选取2020年1月-2021年4月本院收治的96例老年卒中后抑郁患者,采用随机数字表法分为对照组和研究组,各48例。2组均给予基础治疗,对照组另给予草酸艾司西酞普兰片,研究组另给予醒神解郁汤联合针刺治疗。对比2组治疗前后中医症状评分、汉密尔顿抑郁量表(HAMD)及美国国立卫生院神经功能缺损评分(NIHSS)评分、临床疗效。对比2组治疗前后血清5-HT、NE水平。对比2组治疗期间安全性。结果治疗后2组主症、次症评分及总分均下降(P<0.05),治疗后研究组主症、次症评分及总分均低于对照组(P<0.05)。与治疗前相比,治疗后2组HAMD评分、NIHSS评分均降低(P<0.05),研究组治疗后HAMD评分、NIHSS评分均低于对照组(P<0.05)。2组临床疗效比较差异具有统计学意义(P<0.05),且研究组总有效率高于对照组(P<0.05)。与治疗前比较,治疗后2组血清5-HT、NE升高,且研究组高于对照组(P<0.05)。2组不良反无统计学意义(P>0.05)。结论醒神解郁汤联合针刺治疗老年卒中后抑郁患者可缓解患者临床症状,有效降低抑郁症状及神经功能缺损评分,提高临床疗效,调节单胺类神经递质水平,且安全可靠。
Objective To explore the therapeutic efficacy of Xingshen Jieyu Decoction combined with acupuncture on elderly patients with post-stroke depression and the effect on serum serotonin(5-HT)and norepinephrine(NE).Methods A total of 96 elderly patients with post-stroke depression admitted to Qingdao Hospital of Traditional Chinese Medicine from January 2020 to April 2021 were selected and divided into the control group and the study group according to random number table method,with 48 cases in each group.Both groups received the basic treatment.On the basis of this treatment,the control group received escitalopram oxalate tablets,and the study group received Xingshen Jieyu Decoction combined with acupuncture treatment.The traditional Chinese medicine symptom scores,Hamilton Depression Scale(HAMD)and the National Institutes of Health Stroke Scale(NIHSS)scores,and clinical efficacy were compared between two groups before and after treatment.The serum 5-HT and NE levels before and after treatment were compared between two groups.The safety of two groups during treatment was compared.Results After treatment,the scores of primary and secondary symptoms and total scores of two groups decreased(P<0.05).After treatment,the scores of primary and secondary symptoms and total scores of the study group were lower than those of the control group(P<0.05).Compared with before treatment,the HAMD scores and NIHSS scores of two groups decreased after treatment(P<0.05),and the HAMD scores and NIHSS scores of the study group were lower than those of the control group after treatment(P<0.05).There was statistically significant difference in the distribution of clinical effects between two groups(P<0.05),and the total effective rate of the study group was higher than that of the control group(P<0.05).Compared with before treatment,serum 5-HT and NE levels in two groups increased after treatment,and the study group was higher than the control group(P<0.05).There was no statistically significant difference in adverse reactions between two
作者
吕以静
李宁
LV Yijing;LI Ning(Brain Diagnosis and Treatment Center/Department of Neurology,Qingdao Hospital of Traditional Chinese Medicine,Qingdao 266000,China)
出处
《长春中医药大学学报》
2024年第3期291-295,共5页
Journal of Changchun University of Chinese Medicine
基金
山东省自然基金面上项目(ZR202103030420)。
关键词
老年
卒中后抑郁
醒神解郁汤
针刺
5-羟色胺
去甲肾上腺素
elderly
post-stroke depression
Xingshen Jieyu Decoction
acupuncture
serotonin
norepinephrine
