摘要
目的探讨血清成纤维细胞生长因子21(FGF-21)、半乳糖凝集素-3(Gal-3)联合对肥胖型多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)治疗后妊娠结局的预测价值。方法选取2019年2月至2023年2月在南阳市中心医院确诊的98例肥胖型PCOS患者作为研究对象,根据IVF-ET治疗后的妊娠结局分为成功组(n=48)和失败组(n=50);采用酶联免疫吸附测定(ELISA)法检测血清中FGF-21、Gal-3表达水平;受试者工作特征(ROC)曲线分析血清FGF-21、Gal-3联合对肥胖型PCOS患者IVF-ET治疗后妊娠结局的预测价值。采用Logistic回归分析探索肥胖型PCOS患者IVF-ET治疗后妊娠结局的影响因素。结果与成功组比较,失败组LH、FTI、Glu、INS的水平升高,FSH、SHBG水平、Gn天数降低(P<0.05)。与成功组比较,失败组患者FGF-21水平升高,Gal-3水平降低(t=8.412、8.298,P<0.001、<0.001)。FGF-21、Gal-3联合预测肥胖型PCOS患者IVF-ET治疗后妊娠结局的AUC高于FGF-21、Gal-3单独预测的AUC值(Z=14.317,P<0.001;Z=11.793,P<0.001)。多因素Logistic回归分析结果显示,FGF-21、Gal-3为肥胖型PCOS患者IVF-ET治疗后妊娠结局的影响因素(P<0.05)。结论IVF-ET治疗后妊娠失败的肥胖型PCOS患者血清中FGF-21水平升高、Gal-3水平降低,二者对肥胖型PCOS患者IVF-ET治疗后妊娠结局有一定的预测价值。
Objective To explore the predictive value of the combination of serum fibroblast growth factor 21(FGF-21)and galectin-3(Gal-3)for the pregnancy outcomes in obese patients with polycystic ovarian syndrome(PCOS)after in vitro fertilization and embryo transfer(IVF-ET)treatment.Methods A total of 98 obese PCOS patients diagnosed in Nanyang Central Hospital from February 2019 to February 2023 were selected as the study objects.They were divided into a successful group(n=48)and a failed group(n=50)according to their pregnancy outcomes after IVF-ET treatment.Enzyme-linked immunosorbent assay(ELISA)was applied to detect the expression levels of FGF-21 and Gal-3 in serum.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of the combination of serum FGF-21 and Gal-3 for the pregnancy outcomes in obese PCOS patients after IVF-ET treatment.Logistic regression was applied to analyze the influencing factors of pregnancy outcomes in obese PCOS patients after IVF-ET treatment.Results Compared with the successful group,the failed group had increased luteinizing hormone(LH),free testosterone index(FTI),glucose(Glu),insulin(INS)levels and decreased follicle-stimulating hormone(FSH),sex hormone-binding globulin(SHBG)levels and gonadotropin(Gn)days(t=5.524,14.625,2.659,29.303,4.832,8.372,5.871,P<0.001,<0.001,0.009,<0.001,<0.001,<0.001).Compared with the successful group,the failed group had an increased FGF-21 level and a decreased Gal-3 level(t=8.412,8.298,P<0.001,<0.001).The area under the curve(AUC)value of pregnancy outcomes in obese PCOS patients after IVF-ET treatment predicted by the combination of FGF-21 and Gal-3 was higher than that predicted by FGF-21 or Gal-3 alone(Z=14.317,P<0.001;Z=11.793,P<0.001).The results of multivariate Logistic regression analysis showed that FGF-21 and Gal-3 were the influencing factors of pregnancy outcomes in obese PCOS patients after IVF-ET treatment(P<0.05).Conclusion Obese PCOS patients who failed pregnancy after IVF-ET treatment have increased serum FGF-
作者
马圆圆
刘婷婷
徐娜
Ma Yuanyuan;Liu Tingting;Xu Na(Department of Endocrinology,Nanyang Central Hospital,Nanyang 473000,China)
出处
《成都医学院学报》
CAS
2024年第1期39-43,共5页
Journal of Chengdu Medical College
基金
河南省社发领域科技攻关项目(No:2022078)。
