摘要
目的:探讨血红蛋白(Hb)与儿童社区获得性肺炎(CAP)严重程度的相关性及危险因素分析。方法:选取2020年1月—2022年12月于玉林市第二人民医院住院治疗的CAP患儿98例为研究对象,根据CAP严重程度分为轻症CAP组(n=69)和重症CAP组(n=29)。比较轻症CAP组和重症CAP组一般资料,Logistic回归分析探究CAP患儿病情严重程度的独立影响因素。结果:两组患儿性别、年龄、肺炎既往史、感染源、血小板计数、降钙素原水平比较,差异无统计学意义(P>0.05);重症CAP组患儿白细胞计数(WBC)、中性粒细胞计数、血红蛋白(Hp)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平高于CAP组,HB水平低于轻症CAP组,差异有统计学意义(P<0.05)。以WBC、中性粒细胞计数、Hb、IL-6、CRP、TNF-α为自变量,将分组结果(病情严重程度)作为因变量,Logistic回归分析结果显示,Hb、IL-6、TNF-α均是CAP患儿病情严重程度的独立影响因素(P<0.05)。结论:HB水平可作为CAP患儿病情严重程度的临床辅助指标,且HB、IL-6、TNF-α是其独立危险因素。
Objective:To investigate the correlation between hemoglobin(Hb)and the severity of community-acquired pneumonia(CAP)in children and analysis of risk factors.Methods:Ninety-eight children with CAP who were hospitalized in Yulin Second People's Hospital from January 2020 to December 2022 were selected as the study subjects,and were divided into the mild CAP group(n=69)and severe CAP group(n=29)according to the severity of CAP.The general data of the mild CAP group and the se⁃vere CAP group were compared,and binary logistic regression analysis was performed to investigate the independent factors influ⁃encing the severity of CAP.Results:There was no statistically significant difference between the two groups in terms of gender,age,previous history of pneumonia,source of infection,platelet count,and procalcitonin level(P>0.05);The levels of white blood cell count(WBC),neutrophil count,hemoglobin(Hp),interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factoralpha(TNF-alpha)were higher in children in the severe CAP group than in the CAP group,and the levels of Hb were lower than those in the mild CAP group,and the differences were statistically significant(P<0.05);Using WBC,neutrophil count,Hb,IL-6,CRP,and TNF-αas independent variables,and the grouping result(severity of disease)as dependent variable,the results of bina⁃ry logistic regression analysis showed that HB,IL-6,and TNF-αwere independent influences on the severity of the disease in children with CAP(P<0.05).Conclusion:HB level can be used as a clinical auxiliary indicator of disease severity in children with CAP,and HB,IL-6,and TNF-αare its independent risk factors.
作者
唐代炜
温雯
林丽萍
Tang Daiwei;Wen Wen;Lin Liping(Department of Pediatrics,Yulin Second People's Hospital,Yulin 537000,Guangxi,China)
出处
《中外医药研究》
2023年第31期70-72,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
血红蛋白
儿童肺炎
社区获得性肺炎
危险因素
Hemoglobin
Pediatric pneumonia
Community-acquired pneumonia
Risk factors
