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肠道菌群在儿童功能性便秘中作用机制的研究进展 被引量:5

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摘要 功能性便秘(functional consstipation,FC)是儿童时期常见的疾病,给儿童带来严重的痛苦,并降低儿童和父母的生活质量。功能性便秘无性别和年龄区别,全球儿童患病率为9.5%(0.5%~32%),美国和欧洲的儿童患病率明显高于亚洲。我国学龄前儿童功能性便秘发病率为3%~4%,功能性便秘的发病受多种因素影响,如遗传、饮食习惯、代谢等,有研究发现存在童年精神创伤或脾气暴躁、情绪/行为问题和经常发脾气的孩子更容易出现功能性便秘。FC的病理生理学是多因素的,发病机制主要是排便动力学异常。近年来肠道微生物群在功能性便秘中的作用越来越关注,人类肠道中生活着数万亿个微生物细胞[1]。肠道菌群可通过肠道免疫反应释放的介质、细菌发酵的最终产物或肠道神经内分泌因子等机制直接或间接影响肠道运动功能,但是目前关于肠道菌群在这些方面的机制尚不清楚,本文旨在探索和总结肠道菌群在上述方面的作用机制研究进展。
出处 《中国妇幼保健》 CAS 2024年第4期773-775,F0004,共4页 Maternal and Child Health Care of China
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