摘要
中药配伍禁忌作为中医理论的重要组成部分,是关乎中药临床安全有效的关键问题。虽其由来已久,但能否同用争议颇多,暂无统一定论。近年关于中药配伍禁忌的相关研究逐渐增多,对其认识亦不断提升。文章从安全性和有效性两方面,对中药配伍禁忌的研究现状进行探讨。中药配伍禁忌的安全性相关实验提示其成分变化影响其毒性或药效,与临床不良反应事件的发生密切相关;实验和临床研究显示配伍后有增效或治疗作用。建议今后加强中药配伍禁忌成分变化研究、重视不良反应监测、基于临床建立模型开展实验、基于真实世界开展临床研究,从多学科、多领域、多技术交叉融合探究其中科学内涵,以期为临床安全、有效、合理运用配伍禁忌药物提供参考。
Chinese medicine incompatibility,as an important part of traditional Chinese medicine(TCM)theory,is a critical issue concerning the clinical safety and efficacy of TCM.Although it has been long-standing,whether they can be used together is quite controversial,and no uniform conclusion.In recent years,the related studies on the Chinese medicine incompatibility has gradually increased,and the understanding of it has also been continuously improved.This article explores the current research status of Chinese medicine incompatibility from the aspects of safety and efficacy.The safety-related experiments of Chinese medicine incompatibility suggest that the changes of its components affect its toxicity or efficacy,which is closely related to the occurrence of clinical adverse events;experimental and clinical studies have shown synergistic or therapeutic effects after compatibility.It is suggested that in the future,it should strengthen the research on the changes of the ingredients of Chinese medicine compatibility,attach importance to the monitoring of adverse reactions,carry out experiments based on a clinically established model,and carry out clinical research based on the real world,from which multi-disciplinary,multi-field,and multi-technical cross fusion explores the scientific connotation,in order to provide reference for the safe,effective,and rational use of Chinese medicine incompatibility in clinic.
作者
刘晓庆
任彧娜
曹灿
廖文勇
田颐
董肖
徐向楠
吴美晶
李慕云
陈绍红
柳海艳
修琳琳
钟赣生
LIU Xiaoqing;REN Yuna;CAO Can;LIAO Wenyong;TIAN Yi;DONG Xiao;XU Xiangnan;WU Meijing;LI Muyun;CHEN Shaohong;LIU Haiyan;XIU Linlin;ZHONG Gansheng(Beijing University of Chinese Medicine,Beijing 102488,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2024年第1期39-44,共6页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.82274118,No.82104411)。
关键词
中药配伍禁忌
安全性
有效性
研究现状
思考
Chinese medicine incompatibility
Safety
Efficacy
Research status
Considerations
