摘要
在长期的共同进化过程中,噬菌体与细菌宿主之间产生了复杂的相互作用关系。群体感应(quorum sensing,QS)机制在噬菌体和细菌的双向相互作用中扮演了重要角色。综述细菌宿主对群体感应机制的利用,群体感应对生物被膜调节、噬菌体吸附过程以及调控CRISPR-Cas系统等方面所起到的效果,从噬菌体对群体感应机制的介入,总结群体感应机制在噬菌体溶原-裂解性调节以及噬菌体对群体感应机制的抑制,探讨对噬菌体QS机制的挖掘和解析,以期为群体感应机制在噬菌体治疗等领域的应用提供理论依据。
During the extensive co-evolutionary process,complex interactions have emerged between phages and bacterial hosts.Quorum sensing(QS)mechanisms play a prominent role in governing the interactions between phages and bacteria.This article begins by elucidating the exploitation of QS mechanisms by bacterial hosts,providing an overview of their consequential impacts on biofilm regulation,phage adsorption processes,and the modulation of the CRISPR-Cas system.Furthermore,the involvement of phages in QS mechanisms is expounded upon,encompassing a comprehensive survey of their role in phage lytic-lysogenic regulations and the suppression of QS mechanisms.Finally,this article presents a prospective investigation and explanation of phage QS mechanisms,aiming to provide a theoretical foundation for the application of QS mechanisms in the field of phage therapy and related areas.
作者
孙舒扬
吴胜波
张欣乔
梁畅畅
乔建军
SUN Shuyang;WU Shengbo;ZHANG Xinqiao;LIANG Changchang;QIAO Jianjun(School of Chemical Engineering,Tianjin University,Tianjin 300072,China;Zhejiang Institute of Tianjin University(Shaoxing),Shaoxing 312300,China;Key Laboratory of Systems Bioengineering(Ministry of Education),Tianjin University,Tianjin 300072,China;Synthetic Biology Research Platform,Tianjin Collaborative Innovation Center of Chemical Science and Engineering,Tianjin 300072,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2024年第1期107-117,共11页
China Biotechnology
基金
中国博士后科学基金(2023M732599)
国家重点研发计划(2019YFA0905600)
中国创新研究群体基金(21621004)资助项目。
