摘要
目的探究磁共振动态增强(DCE-MRI)定量参数对乳腺癌的诊断价值,并分析定量参数与恶性转化中血管生成的相关性。方法前瞻性选取2020年3月至2022年1月南阳市第二人民医院收治的160例乳腺病变患者,其中浸润性导管癌、导管内原位癌、非典型增生、单纯增生乳腺病变患者各40例。采用磁共振动态增强(DCE-MRI)扫描获取定量参数[细胞外血管外空间的体积分数(Ve)、转运常数(Ktrans)、速率常数(Kep)],比较各组患者DCE-MRI定量参数及血管生成相关因子[血管内生长因子(VEGF)、血管内皮细胞生长因子受体1(Flk-1/KDR)表达、微血管密度],并比较不同病变性质乳腺病变患者DCE-MRI定量参数,采用受试者工作特征曲线(ROC)分析DCE-MRI定量参数联合诊断乳腺癌的价值,采用Pearson相关性分析DCE-MRI定量参数与血管生成相关因子的关系。结果浸润性导管癌组患者的Ve、Ktrans、Kep分别为0.17±0.05、(0.18±0.06)min、(1.37±0.32)min,明显高于导管内原位癌组的0.14±0.04、(0.15±0.04)min、(1.22±0.27)min,非典型增生组的0.12±0.04、(0.05±0.02)min、(0.74±0.07)min和单纯增生组的0.10±0.03、(0.04±0.01)min、(0.53±0.02)min,差异均有统计学意义(P<0.05);浸润性导管癌组患者的Flk-1/KDR半定量积分、VEGF半定量评分及微血管密度分别为(7.44±2.18)分、(7.85±2.46)分、(51.88±3.07)个/100倍镜,明显高于导管内原位癌组的(5.33±1.30)分、(5.72±1.44)分、(31.53±6.51)个/100倍镜,非典型增生组的(3.26±1.65)分、(3.36±1.73)分、(28.74±4.05)个/100倍镜和单纯增生组的(1.06±0.71)分、(1.26±0.74)分、(19.03±4.02)个/100倍镜,差异均有统计学意义(P<0.05);恶性组患者的Ve、Ktrans、Kep分别为0.16±0.05、(0.17±0.05)min、(1.30±0.38)min,明显高于良性组的0.11±0.03、(0.05±0.02)min、(0.64±0.11)min,差异均有统计学意义(P<0.05);经Pearson相关性分析结果显示,Ve、Ktrans、Kep与Flk-1/KDR、VEGF表达及微血管�
Objective To explore the diagnostic value of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in breast cancer,and analyze the correlation between quantitative parameters and angiogenesis in malignant transformation.Methods A prospective study was conducted on 160 patients with breast lesions admitted to Nanyang Second General Hospital from March 2020 to January 2022,including 40 pa-tients with invasive ductal carcinoma, 40 patients with intraductal carcinoma in situ, 40 patients with atypical hyperplasia, and 40 patients with simple hyperplasia breast lesions. Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) scanning was used to obtain quantitative parameters [volume fraction (Ve), transport constant (Ktrans), and rateconstant (Kep) of extracellular vascular space], and DCE-MRI quantitative parameters and angiogenesis-related factors [expression of vascular growth factor (VEGF), vascular endothelial growth factor receptor 1 (Flk-1/KDR), microvascular density] were compared among different groups of patients. DCE-MRI quantitative parameters were also compared among patients with different types of breast lesions. The receiver operating characteristic curve (ROC) was used to analyze the value of DCE-MRI quantitative parameters in the joint diagnosis of breast cancer. Pearson correlation analysis was used to investigate the relationship between quantitative parameters of DCE-MRI and angiogenesis-related factors. Results TheVe, Ktrans, and Kep in the invasive ductal carcinoma group were 0.17±0.05, (0.18±0.06) min, and (1.37±0.32) min, respectively, which were significantly higher than 0.14±0.04, (0.15±0.04) min, and (1.22±0.27) min in the intraductal carcino- ma in situ group, as well as 0.12±0.04, (0.05±0.02) min, and (0.74±0.07) min in the atypical hyperplasia group, and 0.10±0.03, (0.04±0.01) min, and (0.53±0.02) min in the simple hyperplasia group, with statistically significant differences (P<0.05). The Flk-1/KDR semi-quantitative score, VEGF semi-
作者
白丽
苏雪娟
陈体
BAI Li;SU Xue-juan;CHEN Ti(Department of Medical Imaging,Nanyang Second People's Hospital,Nanyang 473000,Henan,CHINA)
出处
《海南医学》
CAS
2024年第4期558-563,共6页
Hainan Medical Journal
基金
河南省南阳市2022年科技攻关项目(编号:KJGG076)。
关键词
磁共振动态增强
乳腺癌
定量参数
恶性转化
血管生成相关因子
Dynamic contrast-enhanced magnetic resonance enhancement
Breast cancer
Quantitative parameter
Malignant transformation
Angiogenesis-related factors
