摘要
目的分析比较己酮可可碱联合甲钴胺治疗糖尿病周围神经病变的疗效及对其神经症状的影响。方法选取2022年1—9月镇江市丹徒区人民医院内分泌科收治的100例2型糖尿病周围神经病患者作为研究对象,以随机数字表法分为常规治疗组(n=50,血栓通/丹参酮治疗)和联合治疗组(n=50,己酮可可碱联合甲钴胺注射液治疗)。比较两组患者治疗后的临床有效率,同时对比其治疗前后的神经症状评分(Neurological Symptom Score,NSS)及神经缺损评分(Neurological Disability Score,NDS)。结果治疗前,两组患者的NDS、NSS评分差异无统计学意义(P均>0.05)。治疗后,两组的NDS、NSS评分均出现下降,且联合治疗组患者的评分明显低于常规治疗组;此外,联合治疗组患者用药后的临床有效率高于常规治疗组,差异有统计学意义(P均<0.05)。结论针对2型糖尿病周围神经病变患者给予己酮可可碱联合甲钴胺治疗可有效提高其临床疗效,同时能在一定程度上改善患者的神经症状及神经缺损情况。
Objective To analyze and compare the efficacy of pentoxifylline combined with mecobalamine in the treat-ment of diabetic peripheral neuropathy and its influence on neurological symptoms.Methods A total of 100 patients with type 2 diabetic peripheral neuropathy admitted to the Endocrinology Department of Dantu District People's Hos-pital of Zhenjiang City from January to September 2022 were selected as the study objects,and were divided into con-ventional treatment group(n=50,thromboxone/tanshinone treatment)and combined treatment group(n=50,pentoxifyl-line combined with mecobalamine injection treatment)by random number table method.The clinical effective rate of the two groups after treatment was compared,and Neurological Symptom Score(NSS)and Neurological Disability Score(NDS)before and after treatment were compared.Results Before treatment,there was no significant difference in NDS and NSS scores between the two groups(both P>0.05).After treatment,NDS and NSS scores of both groups de-creased,and the scores of combined treatment group were significantly lower than that of conventional treatment group;In addition,the clinical effective rate of combined treatment group was higher than that of conventional treat-ment group,and the differences were statistically significant(all P<0.05).Conclusion For patients with type 2 dia-betic peripheral neuropathy,the combination therapy of pentoxifylline and mecobalamine can effectively improve the clinical efficacy,and can improve the neurological symptoms and nerve defects of patients to a certain extent.
作者
解洋
张开凤
袁园
XIE Yang;ZHANG Kaifeng;YUAN Yuan(Department of Endocrinology,Dantu District People's Hospital,Zhenjiang,Jiangsu Province,212100 China)
出处
《糖尿病新世界》
2023年第24期182-184,188,共4页
Diabetes New World Magazine
关键词
己酮可可碱
甲钴胺
糖尿病周围神经病变
神经症状
Pentoxifylline
Mecobalamine
Diabetic peripheral neuropathy
Neurological symptom
