摘要
目的探讨沙库巴曲缬沙坦钠与美托洛尔联合用药对冠心病并发慢性心力衰竭(CHF)患者心功能的影响。方法选择2020年3月至2021年10月绍兴市中心医院医共体总院收治的冠心病并发CHF患者216例,分为观察组和对照组,各108例。两组患者均给予包括美托洛尔的常规治疗,观察组加用沙库巴曲缬沙坦钠。比较两组患者临床疗效、心功能及血清指标水平。结果观察组患者有效率高于对照组,差异有统计学意义(P=0.001)。治疗后观察组舒张早期最大充盈速度(E)、左心室射血分数(LVEF)高于对照组,且高于治疗前,舒张晚期最大充盈速度(A)低于对照组及治疗前,差异均有统计学意义(均P<0.05)。治疗后观察组生长分化因子15、人亲环蛋白、N末端脑钠肽前体水平低于对照组,且低于治疗前,差异均有统计学意义(均P<0.05)。结论沙库巴曲缬沙坦钠联合美托洛尔能明显改善冠心病并发CHF患者的心功能。
Objective To investigate the effect of sacubitril/valsartan combined with metoprolol on cardiac function of patients with coronary artery heart disease(CAD)and chronic heart failure(CHF).Methods A total of 216 patients with CAD and CHF admitted to the Shaoxing Central Hospital from March 2020 to October 2021 were enrolled and divided into an observation group and a control group,with 108 cases in each group.Both groups were given routine treatments including metoprolol succinate sustained-release tablet.The observation group was added with sacubitril/valsartan.The clinical efficacy,cardiac function and serum indexes were compared between the two groups.Results The treatment efficacy was significantly higher in the observation group than in the control group(P=0.001).After treatment,the early diastolic peak filling velocity and left ventricular ejection fraction in the observation group were significantly higher than those in the control group and before treatment,while the late diastolic peak filling velocity was significantly lower than those in the control group and before treatment(all P=0.001).After treatment,growth differentiation factor 15,cyclophilin,and brain natriuretic peptide in the observation group were significantly lower than those in the control group and before treatment(all P<0.05).Conclusion Sacubitril/valsartan combined with metoprolol can effectively improve cardiac function of patients with CAD and CHF.
作者
赵利芳
李文
ZHAO Lifang;LI Wen(Department of Pharmacy,Shaoxing Central Hospital,Shaoxing 312030,China)
出处
《心电与循环》
2024年第1期63-66,共4页
Journal of Electrocardiology and Circulation
关键词
冠心病
慢性心力衰竭
沙库巴曲缬沙坦钠
美托洛尔
Coronary heart disease
Chronic heart failure
Sacubitril/valsartan
Metoprolol
