摘要
目的基于数据挖掘技术研究原发性开角型青光眼(POAG)的中医证候、证素、证型的分布特点及关联规则。方法检索建库至2022年12月31日中国知网(CNKI)、万方、维普(VIP)、中国生物医学文献(CBM)数据库中临床研究、病例报告等相关文献。使用Excel软件进行录入并规范术语,运用R语言对POAG证素、证型、证候进行频数、频率、关联规则分析及可视化。结果(1)一般情况:共纳入文献70篇,共提取中医证素23个,其中病位证素8个,以肝最多,为95次(16.41%),其次为心神(21次,3.63%)、肾(20次,3.45%)等;病性证素15个,以阴虚证素最多,为76次(13.13%),其次为阳亢(57次,9.84%)、气滞(55次,9.50%)、气虚(39次,6.74%)、血虚(39次,6.74%)等;共提取中医证候142个,最多为视物模糊(77次,5.01%),其次为脉弦(66次,4.29%)、眼胀及胀痛(66次,4.29%)、头晕(62次,4.03%)、脉细(58次,3.77%)等;共提取证型31种,最多为肝郁气滞证,共25次(35.71%),其次为肝肾阴虚证(14次,20%)、肝肾两虚证(12次,17.14%)、肝郁化火证(11次,15.71%)、痰湿内蕴证(10次,14.29%)。(2)证素-证候关联规则分析:证素关联较高的组合为①血虚,阳虚-气虚、②阳虚-气虚、③脾-气虚。证候关联较高的组合为①舌苔黄-舌质红、脉弦,②舌苔黄-舌质红、③口苦,舌苔黄-舌质红。证素-证候关联较高的组合为①口苦、脉数、脉弦、舌苔黄、舌质红-热,②口苦、脉弦、舌苔黄、舌质红、食少-热,③口苦、脉数、脉弦、情志抑郁、舌质红-热。(3)核心证素的证候分布规律:口苦、咽干、脉弦与各核心证素均关系密切。结论POAG以肝为核心病位证素,常见的病性证素主要有阴虚、阳亢、气滞、气虚等。证素之间组合关联性强,各核心证素具有特征性全身证候,为POAG的准确辨证提供理论支撑。
OBJECTIVE This study aims to explore the distribution characteristics and association rules of Traditional Chinese Medicine(TCM)syndromes,syndrome elements,and syndrome patterns in primary open-angle glaucoma(POAG)based on data mining techniques.METHODS Literature retrieval and compilation were conducted up to December 31st,2022,from Chinese databases including China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Information,and China Biology Medicine(CBM)database.Clinical studies,case reports,and relevant literature were extracted.Data entry and terminology standardization were performed using Excel software,and the frequency,rate,association rule analysis,and visualization of TCM syndrome elements,syndrome patterns,and syndromes of POAG were conducted using the R language.RESULTS(1)General situation:A total of 70 articles were included,extracting 23 TCM syndrome elements.Among them,the location syndrome elements included eight,with liver being the most frequent(95 times,16.41%),followed by heart spirit(21 times,3.63%),and kidney(20 times,3.45%).There were 15 disease nature syndrome elements,with deficiency syndrome elements being the most Yin deficiency(76 times,13.13%),followed by excessive Yang(57 times,9.84%),Qi stagnation(55 times,9.50%),Qi deficiency(39 times,6.74%),and blood deficiency(39 times,6.74%).A total of 142 TCM syndromes were extracted,with blurred vision being the most frequent(77 times,5.01%),followed by string-like pulse(66 times,4.29%),eye swelling and pain(66 times,4.29%),dizziness(62 times,4.03%),and thin pulse(58 times,3.77%).A total of 31 syndrome patterns were extracted,with liver depression and Qi stagnation pattern being the most frequent,occurring 25 times(35.71%),followed by liver-kidney Yin deficiency pattern(14 times,20%),liver-kidney deficiency pattern(12 times,17.14%),liver depression transforming into fire pattern(11 times,15.71%),and phlegm-dampness internal retention pattern(10 times,14.29%).(2)Analysis of the association rules between syndrome elements and syndromes
作者
孙志超
张丽霞
魏宇娇
倘孟莹
陈爽
SUN Zhichao;ZHANG Lixia;WEI Yujiao;TANG Mengying;CHEN Shuang(Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)
出处
《中国中医眼科杂志》
2024年第3期214-220,共7页
China Journal of Chinese Ophthalmology
基金
国家自然科学基金项目(82074500)
北京市自然科学基金项目(7212197)
中国中医科学院科技创新工程重大攻关项目(CI2021A02605)
中国民族医药学会科研项目(2020ZY356-320301)。
关键词
原发性开角型青光眼
证素
数据挖掘
关联规则
R语言
primary open angle glaucoma
syndrome element
data mining
association rules
R language
