摘要
目的探讨鼓室内甲强龙注射联合高压氧(HBO)治疗全聋型突发性聋患者的不同疗程的临床疗效。方法选取2020年3月至2022年3月郑州人民医院耳鼻喉科收治的全聋型突发性聋患者114例, 采用随机数字表法将患者分为A、B、C组, 每组38例。3组患者按疗程鼓室内注射甲强龙的同时给予HBO治疗。A、B、C组患者注射甲强龙次数分别为3、5、7次, HBO治疗次数分别为10、15、20次, 期间若听力改善连续3次评价为痊愈则停止治疗。各组于治疗前后采用纯音测听(PTA)检测患耳, 依据《突发性聋诊断和治疗指南(2015)》评估听力改善情况及疗效。结果 A、B、C组患者的总有效率分别为63.16%、65.79%、71.05%, 3组间比较差异无统计学意义(P>0.05);治疗后PTA听阈值均低于治疗前, 差异有统计学意义(P<0.05)。结论不同疗程鼓室内甲强龙注射联合HBO治疗全聋型突发性聋均可显著提高患者的听力水平, 但治疗效果差异无统计学意义。建议患者尽早行联合治疗, 同时密切观测治疗过程中出现的不良反应及并发症情况。
Objective To investigate and analyze the clinical efficacies of different courses of intratympanic methylprednisolone perfusion combined with hyperbaric oxygen(HBO)therapy in sudden deafness patients with total hearing loss.Methods We selected 114 sudden deafness patients with total hearing loss who were hospitalized in the department of otorhinolaryngology of Zhengzhou People's Hospital from March 2020 to March 2022.The patients were divided equally into group A,B,and C using the digital random table method,with 38 patients in each group.All the patients were treated according to their own courses,with intratympanic methylprednisolone perfusion being given 3,5,or 7 times,respectively,for group A,B,or C,and HBO therapy for 10,15,20 times,respectively.During treatment,if the patient’s hearing was evaluated as full recovery for three times consecutively,the HBO therapy would therefor be stopped.Pure tone audiometry(PTA)was reviewed before and after the treatment course,according to the Guidelines for Diagnosis and Treatment of Sudden Deafness(2015).Results The total effective rates were 63.16%,65.79%,and 71.05%for group A,B,and C,respectively,with no statistically significant difference(P>0.05).After treatment,the PTAs for all three groups were decreased,with statistically significant differences(P<0.05).Conclusion The combination of intratympanic methylprednisolone perfusion with HBO therapy can significantly improve hearing in sudden deafness patients with total hearing loss despite the courses,but there was no statistically significant difference of the clinical efficacy among the three groups.It is recommended that the combination therapy be performed as early as possible in these patients.The adverse reactions and complications during treatment should be closely monitored at the same time.
作者
刘绪林
张冉
李瑞英
Liu Xulin;Zhang Ran;Li Ruiying(Department of Pharmacy,The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People’s Hospital),Zhengzhou 450000,China;Department of Otorhinolaryngology,Zhengzhou People's Hospital,Zhengzhou 450000,China;Department of Hyperbaric Oxygen Medicine,Zhengzhou People's Hospital,Zhengzhou 450000,China)
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2023年第6期745-749,共5页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
关键词
甲强龙
高压氧
全聋型
突发性聋
鼓室注射
Methylprednisolone
Hyperbaric oxygen
Total deafness
Sudden deafness
Intratympanic injection
