摘要
目的探讨复方丹参滴丸联合阿托伐他汀钙对慢性心力衰竭(congestive heart failure,CHF)患者心功能及细胞因子的影响。方法选取2020年8月—2022年8月就诊于济宁市中医院CHF患者92例进行研究,按照随机数字表法分为2组,各46例。对照组予以阿托伐他汀钙片进行治疗,观察组在对照组基础上采用复方丹参滴丸进行治疗,于治疗3个月后评估。对比2组临床疗效、心功能、细胞因子、血管活性物质、不良反应。结果观察组治疗总有效率(95.65%)高于对照组(80.43%),差异有统计学意义(P<0.05)。治疗前2组心功能、细胞因子、血管活性物质对比,差异无统计学意义(P>0.05);与对照组对比,观察组治疗后左室射血分数(left ventricular ejection fractions,LVEF)高,左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左室收缩末期内径(left ventricular end systolic diameter,LVESD)低,6 min步行距离(six minute walk distance,6MWD)长,可溶性生长刺激表达基因2蛋白(soluble growth stimulation expression gene 2 protein,sST2)、半乳糖凝集素-3(galectin-3)水平均低,内皮素-1(endothelin-1,ET-1)、血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)、脑利钠肽(brain natriuretic peptide,BNP)水平均低(P<0.05)。观察组不良反应(13.04%)与对照组(10.87%)对比,差异无统计学意义(P>0.05)。结论CHF患者经复方丹参滴丸与阿托伐他汀钙治疗后心功能得到显著改善,且血清细胞因子水平趋于正常,血管活性物质生成有效一致,且安全性高。
Objective To investigate the effects of compound Danshen dripping pills combined with atorvastatin calcium on cardiac function and cytokines in patients with chronic heart failure(CHF).Methods A total of 92 CHF patients who visited Ji′ning Traditional Chinese Medicine Hospital from August 2020 to August 2022 were selected for the study.They were divided into two groups using a random number table method,with 46 patients in each group.The control group was treated with atorvastatin calcium tablets,while the observation group was treated with compound Danshen dripping pills on the basis of the control group.Evaluation was conducted after 3 months of treatment.The two groups′clinical efficacy,cardiac function,cytokines,vasoactive substances,and adverse reactions were compared.Results The total effective rate of treatment in the observation group(95.65%)was higher than that in the control group(80.43%),the difference was statistically significant(P<0.05).There was no statistically significant difference in heart function,cytokines,and vasoactive substances between the two groups before treatment(P>0.05).Compared with control group,the left ventricular ejection fractions(LVEF)after treatment in the observation group was higher,and the left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)were lower,six minute walk distance(6MWD)was longer,soluble growth stimulating expressed genes protein 2(sST2),galectin-3 levels,endothelin-1(ET-1),angiotensinⅡ(AngⅡ)and brain natriuretic peptide(BNP)levels were lower(P<0.05).There was no statistically significant difference in adverse reactions between the observation group(13.04%)and the control group(10.87%)(P>0.05).Conclusion The use of compound Danshen dripping pills and atorvastatin calcium in the treatment of CHF patients can improve cardiac function,regulate serum cytokine levels,inhibit the generation of vasoactive substances,and have high safety.
作者
率中泰
刘小娟
SHUAI Zhongtai;LIU Xiaojuan(Department of Cardiovascular,Ji′ning Traditional Chinese Medicine Hospital,Ji′ning Shandong 272000,China)
出处
《中国卫生标准管理》
2024年第3期141-145,共5页
China Health Standard Management
关键词
慢性心力衰竭
复方丹参滴丸
阿托伐他汀钙
心功能
细胞因子
血管活性物质
chronic heart failure
compound Danshen dripping pills
atorvastatin calcium
cardiac function
cytokines
vasoactive substance
