摘要
神经病理性疼痛是一个重要的临床问题,常规药物治疗效果不佳。A型肉毒毒素可缓解多种疼痛,其镇痛作用被认为与神经胶质细胞相关。本文概要介绍A型肉毒毒素作用于神经胶质细胞缓解神经病理性疼痛机制的研究进展,进一步探究A型肉毒毒素在神经病理性疼痛治疗上的临床潜力。
Neuropathic pain is an important clinical problem that is poorly treated with conventional medications.Botulinum toxin type A relieves a wide range of pain,and its analgesic effects are thought to be associated with glial cells.This article summarizes the research progress of the mechanism of botulinum toxin type A acting on glial cells to relieve neuropathic pain,and further explores the clinical potential of botulinum toxin type A in the treatment of neuropathic pain.
作者
潘昱睿
王瑜元
白玉龙
PAN Yurui;WANG Yuyuan;BAI Yulong(Department of Rehabilitation Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China)
出处
《上海医药》
CAS
2024年第3期9-15,共7页
Shanghai Medical & Pharmaceutical Journal
基金
国家自然科学基金青年科学基金项目(82102663)。
