摘要
逍遥丸具有疏肝健脾,调经养血之功效,临床常用于治疗因肝郁脾虚所引起的胸胁胀痛、食欲减退、头晕目眩、月经失调等症。该复方最早可追溯到汉代《伤寒论》记载的四逆散,正式成方于宋代《太平惠民和剂局方》,到明清时代发展成更加充实的方剂如加味八珍汤、加味逍遥丸等制剂。现代已成为治疗肝郁诸多症状的经典方剂。2020年版《中华人民共和国药典》一部对逍遥丸和加味逍遥丸进行收载,现代临床研究对该方治疗范围进一步扩大。通过文献调研,发现逍遥丸临床应用及对其质量分析有一定的报道,但是相关文献缺乏归纳整理。因此,笔者整理相关文献,该文就逍遥丸在治疗乳腺增生、抑郁症、月经不调、黄褐斑、围绝经期综合征/更年期综合征及复方中含有的芍药苷、阿魏酸、甘草酸等成分分析方面进行总结,以期为进一步发挥该经典方剂临床应用、药效作用机制阐明及质量控制等研究奠定基础。
Xiaoyaowan has the effects of soothing the liver,invigorating the spleen,regulating menstruation,and nourishing blood.It is often used to treat the distending pain of the chest and hypochondriac,loss of appetite,dizziness,and irregular menstruation caused by liver depression and spleen deficiency.The formula originated from the Sinisan of Treatise on Cold Damage(《伤寒论》)in the Han dynasty and was officially formulated in the Song dynasty's Taiping Royal Prescriptions(《太平惠民合计局方》).In the Ming and Qing dynasties,it was developed into more comprehensive formulas such as modified Bazhentang,modified Xiaoyaowan,and other formulas.In recent years,Xiaoyaowan has become a classic formula for treating many symptoms of liver depression.The Pharmacopoeia of the People's Republic of China(《中华人民共和国药典》),2020 edition,records Xiaoyaowan and modified Xiaoyaowan.Modern clinical research has further expanded the therapeutic range of this formula.Through literature research,it is found that there are certain reports on the clinical application and quality analysis of Xiaoyaowan,but the relevant literature lacks collation so far.Therefore,relevant literature was consulted and sorted out.The paper summarized the treatment of mammary hyperplasia,depression,irregular menstruation,melasma,menopausal syndrome,and polycystic ovary syndrome with Xiaoyaowan,as well as the quality analysis of paeoniflorin,ferulic acid,and glycyrrhizinic acid of Xiaoyaowan.It is expected to lay a foundation for further research on clinical application,pharmacodynamic mechanism,and quality control of this classic formula.
作者
邓卫芳
裴晓华
DENG Weifang;PEI Xiaohua(Shanxi University of Chinese Medicine,Jinzhong 030619,China;Xiamen Hospital,Dongzhimen Hospital,Beijing University of Chinese Medicine,Xiamen 361015,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第5期272-281,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
山西省自然科学基金青年基金项目(201801D221432)
山西中医药大学科技创新能力培育计划项目(2019PY-072)。
