摘要
目的观察艾迪注射液联合化疗对肺癌脑转移患者认知障碍的缓解情况。方法回顾性分析2018年6月至2020年6月在浙江省丽水市人民医院就诊的80例肺癌脑转移患者的临床资料,按照不同治疗方法分为常规化疗组和艾迪组,常规化疗组患者采用顺铂联合多西他赛的化疗方案,艾迪组在常规化疗组基础上予以艾迪注射液。观察2组患者的近期疗效、认知功能以及毒副作用,评价联合艾迪注射液治疗的有效性和安全性。结果常规化疗组患者近期有效率50%,艾迪组患者近期有效率73%,2组差异有统计学意义(χ^(2)=4.266,P=0.039)。治疗开始前,常规化疗组和艾迪组患者的蒙特利尔认知评估量表(MoCA)评分和简易智能量表(MMSE)评分差异无统计学意义。治疗后2周,与常规化疗组比较,艾迪组患者的MoCA评分和MMSE评分均增加,差异具有统计学意义(t=-3.462、-2.507,P=0.001、0.047);治疗后2周艾迪组患者的Karnofsky评分和生活质量量表(QOL)评分升高,差异具有统计学意义(t=-4.634、-4.050,P<0.01)。与常规化疗组比较,艾迪组患者骨髓抑制和眩晕情况减轻,差异具有统计学意义(χ^(2)=4.126、4.050,P=0.042、0.044),恶心呕吐等胃肠道反应和脱发情况差异无统计学意义(P>0.05)。80例患者均因本病死亡。常规化疗组患者平均生存期为(15±3)个月,艾迪组患者的中位生存期为(18±4)个月,2组差异无统计学意义(χ^(2)=17.752,P<0.01)。结论艾迪注射液联合常规化疗方案治疗肺癌脑转移患者可提升近期疗效,缓解认知障碍,减轻化疗的毒副作用,但对于患者的生存期无明显影响。
Objective To observe the clinical application of Aidi Injection combined with conventional chemotherapy in patients with lung cancer brain metastases.Methods A retrospective analysis was conducted on the clinical data of 80 patients with lung cancer brain metastasis who visited the Lishui People′s Hospital from June 2018 to June 2020.They were divided into conventional chemotherapy group and Aidi group based different treatment methods.Patients in the conventional chemotherapy group received chemotherapy with cisplatin com-bined with docetaxel,while patients in the Aidi group received Aidi Injection in addition to conventional chemotherapy.The short-term efficacy,cognitive function,and adverse reactions between the two groups were compared,and the effectiveness and safety of this combination therapy approach were evaluated.Results Com-pared with the conventional chemotherapy group,the short-term effective rate of patients in the Aidi group was higher(χ^(2)=4.266,P=0.039),50%for the conventional chemotherapy group,and 73%for the Aidi group.Before the treatment initiation,there was no statistically significant difference in the MoCA scores and MMSE scores between the two groups.After 2 weeks of treatment,compared with the conventional chemotherapy group,the MoCA and MMSE scores in the Aidi group were significantly increased(t=-3.462,-2.507;P=0.001,0.047);and the Karnof-sky scores and QOL scores in the Aidi group were also significantly increased(t=-4.634,-4.050;P<0.01).Com-pared with the conventional chemotherapy group,patients in the Aidi group showed a significant reduction in bone marrow suppression and dizziness(χ^(2)=4.126,4.050;P=0.042,0.044),while gastrointestinal reactions such as nausea and vomiting and hair loss had been alleviated,but the difference was not statistically significant(P>0.05).All 80 patients mentioned above ultimately died due to this disease.The median survival period for the con-ventional chemotherapy group was(15±3)months,while it was(18±4)months for the Aidi group.The difference
作者
柳桂菊
李露
赵青青
陈婧婧
潘炯伟
Liu Guiju;Li Lu;Zhao Qingqing;Chen Jingjing;Pan Jiongwei(Department of Respiratory Medicine,Lishui People′s Hospital,Lishui,Zhejiang 323000,China)
出处
《中国药物与临床》
CAS
2024年第2期102-106,F0003,共6页
Chinese Remedies & Clinics
基金
浙江省科技计划项目(2016C33243)。
关键词
艾迪注射液
化疗
肺肿瘤
脑转移
认知功能
临床疗效
Ai Di Zhu She Ye
Chemotherapy
Lung neoplasms
Brain metastasis
Cognitive function
Clinical efficacy
