摘要
目的探讨熊去氧胆酸联合瑞舒伐他汀治疗脂肪肝的效果。方法选取2022年1月—2023年1月枣庄市峄城区人民医院收治的80例脂肪肝患者为研究对象,采用随机数表法分为观察组和对照组,各40例。对照组单用熊去氧胆酸,观察组联用瑞舒伐他汀。对比两组总有效率、肝功能指标、炎性因子指标、血脂指标、不良反应发生率。结果观察组总有效率(97.50%)高于对照组,差异有统计学意义(χ2=6.135,P<0.05)。治疗后,两组肝功能指标、炎症因子指标均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。治疗后,两组血脂指标优于治疗前,且观察组优于对照组,差异有统计学意义(P均<0.05)。两组均未见明显不良反应。结论熊去氧胆酸联合瑞舒伐他汀治疗脂肪肝,可提高总有效率,改善肝功能,降低炎性反应程度,改善血脂指标,且具一定安全性。
Objective To investigate the efficacy of ursodeoxycholic combination with Rosuvastatin in the treatment of fatty liver.Methods Eighty cases of patients with fatty liver admitted to Yicheng District People's Hospital of Zao⁃zhuang from January 2022 to January 2023 were selected as the research object and divided into observation group and control group of 40 cases each using the random number table method.The control group used ursodeoxycholic acid alone,and the observation group combined with Rosuvastatin.Compared the total effective rate,liver function in⁃dexes,inflammatory factor indexes,blood lipid indexes,and incidence of adverse reaction between the two groups.Re⁃sults The total effective rate of the observation group(97.50%)was higher than that of the control group,and the differ⁃ence was statistically significant(χ2=6.135,P<0.05).After treatment,all liver function indexes and inflammatory fac⁃tor indexes of both groups were reduced,and the observation group was lower than the control group,and the differ⁃ence was statistically significant(all P<0.05).After treatment,the lipid indexes of both groups were better than before treatment,and the observation group was better than the control group,the difference was statistically significant(all P<0.05).No obvious adverse reactions were seen in both groups.Conclusion Ursodeoxycholic acid combined with Rosuv⁃astatin in the treatment of fatty liver can increase the overall effective rate,improve liver function,reduce the degree of inflammatory response,improve blood lipid indexes,and has a certain safety.
作者
巴莹
黄静
李琳
BA Ying;HUANG Jing;LI Lin(Department of Pharmacy,Yicheng District People's Hospital,Zaozhuang,Shandong Province,277300 China;De-partment of Disinfection Supply Center,Yicheng District People's Hospital,Zaozhuang,Shandong Province,277300 China)
出处
《系统医学》
2023年第24期178-181,共4页
Systems Medicine
关键词
脂肪肝
瑞舒伐他汀
熊去氧胆酸
肝功能
炎性因子
Fatty liver
Rosuvastatin
Ursodeoxycholic acid
Liver function
Inflammatory factor
