摘要
目的 探究颅内血管介入联合依达拉奉右莰醇注射液对老年急性缺血性脑血管病(AICVD)的临床研究。方法 随机选取宿迁市第一人民医院神经内科在2021年2月—2023年1月收治的老年AICVD患者86例纳入本次研究,将患者按照随机数字法分为对照组(43例)和研究组(43例)。对照组行颅内血管介入治疗,研究组行颅内血管介入联合依达拉奉右莰醇注射液治疗。比较两组病灶位置、介入治疗方式、血管内皮功能、神经功能、氧化应激、凝血功能、用药安全性。结果 两组病灶位置及介入治疗方式比较无统计学差异(P>0.05)。治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分、神经元特异性烯醇化酶(NSE)、同型半胱氨酸(Hcy)水平均低于治疗前(P<0.05),研究组低于对照组(P<0.05)。治疗后,两组一氧化氮(NO)水平均高于治疗前(P<0.05),研究组高于对照组(P<0.05)。治疗后,两组谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平均高于对照组(P<0.05),研究组高于对照组(P<0.05)。治疗后,两组血小板聚集率水平均低于治疗前(P<0.05),研究组低于对照组(P<0.05)。两组不良反应无统计学差异(P>0.05)。结论 对老年AICVD患者行颅内血管介入联合依达拉奉右莰醇治疗,可明显促进神经功能恢复,改善血管内皮功能及氧化应激,确保血液流动顺畅,有效促进恢复,同时用药具有较高安全性。
Objective To investigate the clinical effects of intracranial vascular intervention combined with edaravone dextanol injection in elderly patients with acute ischemic cerebrovascular disease(AICVD).Methods Eighty six elderly patients with AICVD admitted to the neurology department of the first people′s Hospital of Suqian between February 2021 and January 2023 were randomLy selected for inclusion in this study.They were divided into control(forty-three cases)and study(forty-three cases)groups according to the random number table method.;The lesion location,interventional therapy,nerve function,vascular endothelial function,oxidative stress response,coagulation function,and drug safety were compared between the two groups.Results There was no significant difference in lesion location and interventional treatment method between the two groups(P>0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)scores,neuron specific enolase(NSE),and homocysteine(Hcy)levels were lower than before treatment in both groups(P<0.05),they were lower in the study group than in the control group(P<0.05).After treatment,nitric oxide(NO)levels in both groups were higher than before treatment(P<0.05),it was higher in the study group than in the control group(P<0.05).After treatment,glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)levels were higher in both groups than before treatment(P<0.05),they were higher in the study group than in the control group(P<0.05).After treatment,platelet aggregation rate levelin both groups were lower than those before treatment(P<0.05),it was lower in the study group than in the control group(P<0.05).There was no statistically difference in adverse effects between the two groups(P>0.05).Conclusion Treatment of elderly patients with AICVD with intracranial vascular intervention combined with edaravone dexbuprenol significantly promoted neurological recovery,improved vascular endothelial function and oxidative stress,ensured smooth blood flow,and effectively promoted recovery.
作者
郑圆
王萱
陈芳芳
程弘禹
ZHENG Yuan;WANG Xuan;CHEN Fangfang;CHENG Hongyu(Suqian First People′s Hospital,Suqian Jiangsu 223800,China)
出处
《中国急救复苏与灾害医学杂志》
2024年第2期203-206,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
宿迁市科技计划项目(编号:SY202211)。
关键词
急性缺血性脑血管病
颅内血管介入术
依达拉奉右莰醇注射液
氧化应激
神经功能
Acute ischemic cerebrovascular disease
Intracranial vascular intervention
Edaravone dexborneol injection
Oxidative stress
Neural function
