摘要
趋避冲突(AAC)是个体在面对相互矛盾的趋近或回避的想法时所发生的内部冲突,其反映了以过度趋近或过度回避为代表的焦虑、抑郁和成瘾等精神疾病的某些特征。皮质-边缘-纹状体系统的功能在神经层面影响着AAC发生时的行为选择,发展能够更好地体现AAC的相关行为学范式在评估药物疗效和指导新药开发方面意义重大。本文从精神药理学方面系统地总结了与AAC行为相关的神经机制、行为学范式及这些范式在行为药理学方面的应用,以期为诊断和治疗相关神经精神疾病提供新的视角和方法。
Approach-avoidance conflict(AAC)refers to the internal conflict that individuals experi⁃ence when faced with conflicting approach or avoidance thoughts.It reveals some characteristics of mental disorders,such as anxiety,depression,and addiction represented by excessive tendencies of approach or avoidance.The function of the cortico-limbic-striatal system influences behavioral choices at the neural level during the onset of AAC,and the development of related behavioral paradigms that can better represent AAC behaviors is critical to evaluating the efficacy of drugs and guiding the development of new drugs.This paper summarizes the neural mechanisms,behavioral paradigms,and applications in behavioral pharmacology related to AAC behaviors from the perspective of psychopharmacology with a view to providing new perspectives and methods for the diagnosis and treatment of related neuro⁃psychiatric disorders.
作者
张志博
贾靖仪
文睿婷
曾令高
梁建辉
ZHANG Zhibo;JIA Jingyi;WEN Ruiting;ZENG Linggao;LIANG Jianhui(Department of Molecular and Cellular Pharmacology,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Department of Pharmacy,Peking University People′s Hospital,Beijing 100044,China;NMPA Key Laboratory of Quality Monitoring of Anaesthetic and Psychotropic Substances,Chongqing Institute for Food and Drug Control,Chongqing 401121,China)
出处
《中国药理学与毒理学杂志》
CAS
北大核心
2024年第2期144-152,共9页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(82173799)。
关键词
趋避冲突
精神障碍
皮质-边缘-纹状体系统
梁氏情境应激箱
approach-avoidance conflict
mental disorder
cortical-limbic-striatum circuit
Liang′s contextual-stress box
