摘要
目的分析黄荧光染色技术引导荧光显微镜下肿瘤切除术治疗小脑幕上胶质瘤患者的临床效果。方法选取中国人民解放军联勤保障部队第901医院2016年1月至2019年3月收治的小脑幕上胶质瘤患者98例,根据治疗方式不同分为传统手术组(48例)与黄荧光技术组(50例)。传统手术组采取传统显微外科肿瘤切除术治疗,黄荧光技术组采取黄荧光染色技术引导进行荧光显微镜下肿瘤切除术治疗。比较两组手术情况(手术时间、肿瘤完全切除率及术后住院时间)、术后并发症情况(肢体运动障碍、脑水肿及肺部感染),以及两组术前及术后的卡氏评分(KPS)。随访2年,比较两组无进展生存期(PFS)、总生存期(OS)。结果两组手术时间比较差异无统计学意义(P>0.05),黄荧光技术组肿瘤完全切除率高于传统手术组(84.00%vs.58.33%),住院时间短于传统手术组[(12.86±2.68)d vs.(18.41±3.24)d],差异有统计学意义(P<0.05);两组在肢体运动障碍、脑水肿及肺部感染等术后并发症发生率差异均无统计学意义(P>0.05);术后1个月,黄荧光技术组的KPS评分高于对照组[(80.24±13.35)分vs.(74.37±12.33)分],差异有统计学意义(P<0.05);随访发现,两组患者PFS、OS比较,差异均有统计学意义(P<0.05)。结论黄荧光染色技术引导荧光显微镜下肿瘤切除术治疗小脑幕上胶质瘤,可提高肿瘤完全切除率,缩短患者住院时间,促进患者术后生存质量改善,对改善患者预后生存情况具有一定临床意义。
Objective To analyze the clinical effect of tumor resection under a fluorescent microscope guided by yellow fluorescence staining in the treatment of patients with supratentorial glioma.Methods A total of 98 patients with supratentorial glioma admitted to The No.901 Hospital of the Joint Logistic Support Force of People’s Liberation Army from January 2016 to March 2019 were selected and divided into a traditional surgery group(48 cases)and a yellow fluorescence technique group(50 cases)according to different treatment methods.The traditional surgery group was treated with traditional microsurgical tumor resection,while the yellow fluorescence technique group was treated with yellow fluorescence staining technology to guide tumor resection under the microscope.The surgical conditions(operation time,complete tumor resection rate,and postoperative hospital stay),postoperative complications(limb movement disorder,brain edema,and pulmonary infection),as well as preoperative and postoperative Karnofsky Performance Score(KPS)between the two groups were compared.After 2 years of follow-up,progression-free survival(PFS)and overall survival(OS)were compared between the two groups.Results There was no significant difference in the operation time between the two groups(P>0.05).The tumor complete resection rate in the yellow fluorescence technique group was higher than that in the traditional surgery group(84.00%vs.58.33%),and the hospital stay was shorter than that in the traditional surgery group[(12.86±2.68)%)d vs.(18.41±3.24)d],the difference was statistically significant(P<0.05).There was no significant difference in the incidence of postoperative complications such as limb movement disorder,brain edema,and pulmonary infection between the two groups(P>0.05).One month after the operation,the KPS score of the yellow fluorescence technique group was higher than that of the control group[(80.24±13.35)points vs.(74.37±12.33)points],and the difference was statistically significant(P<0.05).Follow-up showed that there were
作者
雷钟奇
刘家传
王金标
温玉东
姚寅生
武孝刚
王春琳
LEI Zhongqi;LIU Jiachuan;WANG Jinbiao;WEN Yudong;YAO Yinsheng;WU Xiaogang;WANG Chunlin(Department of Neurosurgery,the No.901 Hospital of the Joint Logistic Support Force of People’s Liberation Army,Hefei 230000,China)
出处
《中国肿瘤外科杂志》
CAS
2023年第6期541-545,共5页
Chinese Journal of Surgical Oncology
基金
安徽省重点研究和开发计划项目(201904a07020108)。
关键词
小脑
幕上胶质瘤
荧光染色
肿瘤切除术
Cerebellum
Supratentorial glioma
Fluorescent staining
Tumor resection
