摘要
脂基纳米粒子是一种天然的食品级胶体传输载体,用于疏水性生物活性物质的递送,可有效提高活性物质的水分散性、稳定性以及生物利用度,具有良好的开发应用前景。作为具有降胆固醇等多种功能特性的一类天然甾体化合物,植物甾醇的低水溶性、油溶性,高结晶度,很大程度地限制了其在食品中的添加和应用。综述了脂基纳米粒子的类型及其特点、脂基纳米粒子的研究现状、植物甾醇的功能特性及其在食品应用中的瓶颈、脂基纳米粒子用于植物甾醇递送的研究进展,详细介绍了目前关于植物甾醇-脂基纳米粒子的构建、物化特性及其在消化方面的研究进展、多组分复合对于植物甾醇-脂基纳米粒子的优化和改性等,并对脂基纳米粒子在细胞及体内层面研究的必要性进行了展望。期望这种新型胶体递送体系为拓展植物甾醇在低脂或水分散性功能食品或饮料中的应用提供一个良好的思路。
Lipid-based nanoparticles are a natural food grade colloidal transport carrier used for the delivery of hydrophobic bioactive substances,which can effectively improve the water-dispersibility,stability,and bioavailability of active substances,and thus have good development and application prospects.As a class of natural steroid compound with various functional properties such as cholesterol lowering,phytosterols are greatly limited for their addition and application in food field because of the low water-and oil-solubility,and high crystallinity.This article reviewed the types and characteristics of lipid-based nanoparticles,the current research status of lipid-based nanoparticles,the functional characteristics of phytosterols and their bottlenecks in food applications,and the research progress of lipid-based nanoparticles for phytosterol delivery.It provided a detailed introduction to the construction,physicochemical properties,and research progress in digestion of phytosterols loaded lipid-based nanoparticles.Besides,the optimization and modification of phytosterols loaded lipid-based nanoparticles through multi-component interaction were discussed,and the necessity of studying lipid-based nanoparticles at the cellular and in vivo levels was also prospected.It is expected that this new colloidal delivery system will provide a good approach for expanding the application of phytosterols in low-fat or water-dispersible functional foods such as beverages.
作者
郭姝婧
汪学德
胡毓元
王童
马传国
GUO Shujing;WANG Xuede;HU Yuyuan;WANG Tong;MA Chuanguo(College of Food Science and Engineering,Henan University of Technology,Zhengzhou 450001,China)
出处
《河南工业大学学报（自然科学版）》
CAS
北大核心
2023年第6期123-131,共9页
Journal of Henan University of Technology：Natural Science Edition
关键词
植物甾醇
脂基纳米粒子
胶体传输
功能食品
phytosterols
lipid based nanoparticles
colloidal transport
functional foods
