摘要
【目的】探讨清眩解郁汤对老年高血压眩晕患者血压及同型半胱氨酸(Hcy)、血管内皮生长因子(VEGF)水平的影响。【方法】在两院就诊的102例老年高血压眩晕患者,随机分为观察组(清眩解郁汤+西药治疗)与对照组(西药治疗),每组51例。比较两组患者的治疗效果、不良反应及治疗前后的中医证候积分、收缩压(SBP)、舒张压(DBP)、眩晕评定量表评分系统(DARS)评分、Hcy和VEGF水平。【结果】观察组总有效率为88.24%,显著高于对照组的70.59%(P<0.05);两组治疗后眩晕、头痛、胸闷、烦躁、心悸、失眠多梦评分显著低于治疗前,且观察组低于对照组(P<0.05);两组治疗后SBP、DBP、DARS评分显著低于治疗前(P<0.05),且观察组低于对照组(P<0.05);两组治疗后Hcy、VEGF水平显著低于治疗前,且观察组低于对照组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】清眩解郁汤可缓解老年高血压眩晕患者的眩晕症状,控制血压水平,保护血管内皮功能,且不良反应少。
【Objective】To explore the effects of Qingxuan Jieyu Decoction on blood pressure and levels of homocysteine(Hcy)and vascular endothelial growth factor(VEGF)in elderly patients with hypertension and vertigo.【Methods】A total of 102 elderly patients with hypertension and vertigo treated at two hospital were randomly divided into an observation group(Qingxuan Jieyu Decoction+Western medicine treatment)and a control group(Western medicine treatment),with 51 patients in each group.The therapeutic effect,adverse reactions,traditional Chinese medicine(TCM)syndrome scores,systolic blood pressure(SBP),diastolic blood pressure(DBP),dizziness assessment rating scale(DARS)scores,and levels of Hcy and VEGF before and after treatment were compared in both groups.【Results】The total effective rate in the observation group was 88.24%,which was significantly higher than 70.59%in the control group(P<0.05).After treatment,scores for vertigo,headache,chest tightness,irritability,palpitations,and insomnia in both groups were significantly lower than before treatment,with the observation group showing even lower scores than the control group(P<0.05).After treatment,SBP,DBP,and DARS scores in both groups were significantly lower than before treatment(P<0.05),and the observation group showed even lower scores of SBP,DBP,and DARS than the control group(P<0.05).After treatment,levels of Hcy and VEGF in both groups were significantly lower than before treatment,while levels of Hcy and VEGF in the observation group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in both groups showed no significant difference(P>0.05).【Conclusion】Qingxuan Jieyu Decoction can effectively alleviate vertigo symptoms in elderly patients with hypertension and vertigo,control blood pressure levels,protect vascular endothelial function,and has few adverse reactions.
作者
王亮
王晓绒
WANG Liang;WANG Xiaorong(Department of Internal MedicineⅣ,Shangluo City Traditional Chinese Medicine Hospital,Shangluo Shaanxi 726000)
出处
《医学临床研究》
CAS
2024年第1期54-57,共4页
Journal of Clinical Research
