摘要
肝纤维化是肝纤维结缔组织异常增殖的一个重要病理变化,也是形成肝硬化的必要条件。白细胞介素6(interleukin 6,IL-6)是一种具有多效生物活性的炎性细胞因子,其在肝纤维化形成过程中起着关键性的作用。大量研究表明IL-6与肝纤维化的发生发展密切相关。本文就IL-6与病毒、药物、毒物、肥胖、酒精、胆汁淤积性及自身免疫等原因所致肝纤维化的相关性做简要阐述,以期能为肝纤维化的诊断及其预后提供一种新的非侵入性标志物。
Liver fibrosis is an important pathological change characterized by the abnormal proliferation of hepatic fibrous connective tissue,and it is also a prerequisite for the development of liver cirrhosis.Interleukin 6(IL-6)is a multi-functional pro-inflammatory cytokine that plays a key role in the formation of liver fibrosis.Numerous studies have shown that IL-6 is closely related to the occurrence and progression of liver fibrosis.This article briefly discusses the correlation between IL-6 and liver fibrosis caused by various factors such as viruses,drugs,toxins,obesity,alcohol,cholestasis,and autoimmunity,with the hope of providing a new non-invasive biomarker for the diagnosis and prognosis of liver fibrosis.
作者
郭晓玲
张耀武
Guo Xiaoling;Zhang Yaowu(Fenyang College of Shanxi Medical University,Lv Liang 032200,China;Department of Infectious Diseases,Fenyang Hospital Affiliated of Shanxi Medical University,Lv Liang 032200,China)
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2023年第5期526-531,共6页
Chinese Journal of Histochemistry and Cytochemistry
基金
山西省基础研究项目(20210302123436)。
