摘要
全球范围内慢性肾脏病(CKD)的发病率和死亡率逐渐升高。肾脏纤维化几乎是所有进展性肾脏疾病的结果,受多种信号通路调控,迄今为止仍缺乏有效遏制肾脏纤维化进展的方法。芳香烃受体(AHR)作为碱性螺旋/环/螺旋per-Arnt-sim(bHLH-PAS)超家族成员,是一种配体依赖性转录因子,广泛表达于多种类型细胞,参与多种生物学过程。研究表明AHR通过与多种信号通路相串扰,在组织纤维化进展中发挥重要作用。色氨酸代谢产物作为AHR配体,对肾脏纤维化的形成有促进作用,研究已证实靶向色氨酸代谢的药物可通过AHR及信号通路来调节纤维化,为肾脏纤维化的治疗开辟了新途径。
The morbidity and moratily of chronic kidney disease(CKD)are increasing worldwide.Renal fibrosis is the result of almost all progressive renal diseases and is regulated by multiple signaling pathways.So far,there are few therapies targeting signaling pathways to slow down fibrosis.As a member of the basic helix/ring/helix per Arnt-sim(bHLH-PAS)superfamily,aromatic hydrocarbon receptor(AHR)is a ligand-dependent transcription factor widely expressed in many cell types and involved in many biological processes.The function of AHR is not fully understood,but it has been shown to play an important role in the progression of tissue fibrosis through its crosstalk with a variety of signaling pathways.Tryptophan metabolite,as a ligand of AHR,can promote the formation of renal fibrosis.Studies have confirmed that drugs targeting tryptophan metabolism can regulate fibrosis through AHR and signaling pathways,opening up a new way for the treatment of renal fibrosis.
作者
俞肄茹
谢红浪
YU Yiru;XIE Honglang(National Clinical Research Center for Kidney Diseases,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210016,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2023年第6期563-568,共6页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
芳香烃受体
信号通路
肾脏纤维化
色氨酸代谢产物
aryl hydrocarbon receptor
signaling pathways
renal fibrosis
tryptophan metabolites
