摘要
目的评价全静脉营养支持疗法治疗早产及危重新生儿的疗效。方法86例早产及危重新生儿,根据不同疗法分为A组(43例)与B组(43例)。A组采用常规营养支持疗法,B组采用全静脉营养支持疗法。比较两组新生儿的临床治疗时间(营养支持时间、达全胃肠道喂养时间、恢复出生体重时间、住院时间)、营养指标(白蛋白、球蛋白、前白蛋白)、生长发育指标(体重增长、身长增长、头围增长)、不良事件发生情况(胃肠功能紊乱、高脂血症、高血糖、氮质血症)、预后情况(死亡、治愈)。结果B组营养支持时间(9.54±2.76)d、达全胃肠道喂养时间(7.04±1.45)d、恢复出生体重时间(5.52±1.03)d、住院时间(12.41±1.97)d短于A组的(12.47±3.68)、(8.68±1.93)、(7.46±1.15)、(14.72±2.14)d(P<0.05)。B组治疗后的白蛋白(38.70±3.65)g/L、球蛋白(22.18±2.73)g/L、前白蛋白(171.91±16.03)g/L高于A组的(33.36±2.79)、(18.32±2.26)、(145.25±16.82)g/L(P<0.05)。B组体重增长(0.52±0.16)kg、身长增长(1.52±0.43)cm、头围增长(1.19±0.36)cm大于A组的(0.38±0.11)kg、(1.24±0.30)cm、(1.02±0.27)cm(P<0.05)。B组的不良事件发生率4.65%低于A组的18.60%(P<0.05)。B组的治愈率93.02%高于A组的74.42%(P<0.05);两组死亡率比较无差异(P>0.05)。结论全静脉营养支持疗法治疗早产及危重新生儿的疗效较好,可缩短临床治疗时间,改善新生儿营养指标,促进其生长发育,且可降低不良事件发生率,改善新生儿预后,值得推行应用。
Objective To evaluate the efficacy of total parenteral nutrition support therapy on premature and critically ill neonates.Methods 86 cases of premature and critically ill neonates were divided into group A(43 cases)and group B(43 cases)according to different treatments.Group A received conventional nutritional support therapy,and group B received total parenteral nutrition support therapy.Comparison was made on clinical treatment time(nutritional support time,time to full enteral feeding,birth weight recovery time,hospitalization time),nutritional indicators(albumin,globulin,prealbumin),growth and development indicators(weight gain,height growth,head circumference growth),adverse events(gastrointestinal dysfunction,hyperlipidemia,hyperglycemia,azotemia),and prognosis(death and cure)between the two groups.Results The nutritional support time of group B was(9.54±2.76)d,the time to full enteral feeding was(7.04±1.45)d,the birth weight recovery time was(5.52±1.03)d,and the hospitalization time was(12.41±1.97)d,which were shorter than(12.47±3.68),(8.68±1.93),(7.46±1.15),and(14.72±2.14)d of group A(P<0.05).After treatment,group B had albumin of(38.70±3.65)g/L,globulin of(22.18±2.73)g/L and prealbumin of(171.91±16.03)g/L,which were higher than(33.36±2.79),(18.32±2.26)and(145.25±16.82)g/L in group A(P<0.05).The weight gain,height growth,head circumference growth of group B were(0.52±0.16)kg,(1.52±0.43)cm and(1.19±0.36)cm,which were greater than(0.38±0.11)kg,(1.24±0.30)cm and(1.02±0.27)cm of group A(P<0.05).The incidence of adverse events in group B was 4.65%,which was lower than 18.60%in group A(P<0.05).The cure rate of 93.02%in group B was higher than 74.42%in group A(P<0.05).There was no difference in death rate between the two groups(P>0.05).Conclusion Total parenteral nutrition support therapy has good efficacy in the treatment of premature and critically ill neonates,which can shorten the clinical treatment time,improve the nutritional indicators of neonates,promote their growth and development,r
作者
王飞鸽
WANG Fei-ge(Department of Neonatology,Xinyi People's Hospital,Xinyi 221400,China)
出处
《中国现代药物应用》
2024年第3期64-67,共4页
Chinese Journal of Modern Drug Application
关键词
全静脉营养支持疗法
早产
危重新生儿
营养指标
生长发育指标
Total parenteral nutrition support therapy
Premature birth
Critically ill neonates
Nutritional indicators
Growth and development indicators