摘要
目的探讨胃肠道间质瘤(GIST)的临床特点及病理学特点。方法选取75例胃肠道间质瘤患者为研究对象,采用回顾性分析法记录所有数据。统计分析胃肠道间质瘤的临床特征、病理数据、免疫组化检测结果、CT检查特征。结果75例胃肠道间质瘤患者中,年龄>50岁的患者占68.00%(51/75);存在腹部痛疼或肿胀不适的患者占42.67%(32/75);发生黑便、消化道出血等症状的患者占34.67%(26/75);发生腹部肿块的患者占22.67%(17/75)。发生腹部压痛感的患者占33.33%(25/75);能够检测到腹部肿块的患者占36.00%(27/75);经肠道检查发现肿块的患者占10.67%(8/75);无明显临床症状或阳性体征反应的患者占20.00%(15/75)。经实验室检查后证实:白蛋白或总蛋白下降的患者占20.00%(15/75)、便常规潜血形成的患者占38.67%(29/75)、血红蛋白降低的患者占41.33%(31/75)。75例胃肠道间质瘤患者中,病理分级为极低危险度的患者占10.67%(8/75),低危险度的患者占22.67%(17/75),中等危险度的患者占24.00%(18/75),高危险度的患者占42.67%(32/75)。胃肠道间质瘤细胞形态组织学特征为梭形或上皮样。75例胃肠道间质瘤患者中,CD117阳性表达率高达94.67%,CD34阳性表达率高达72.00%,部分患者神经元特异性烯醇化酶(NSE)、平滑肌肌动蛋白(SMA)、S-100、PGP915呈阳性表达。75例胃肠道间质瘤患者中,59例胃肠道间质瘤患者CT检查结果为膨胀生长,呈现为椭圆状或球形的肿块,其中28例患者CT形态呈分叶状。34例患者CT平扫肿块密度相对均匀的占29例,51例患者的病灶影像学显示有出血、囊变和不同程度坏死等病变,28例患者显示肿块病灶边界清晰,32例患者显示肿块边界模糊且与周边的相关脏器粘连。75例胃肠道间质瘤患者中均未发现病灶钙化。增强CT扫描结果显示,不均匀强化病例为50例,中度强化的病例为17例,轻度强化的病例为8例。结论通过观察并分析胃肠道�
Objective To investigate the clinical and pathological features of gastrointestinal stromal tumor(GIST).Methods 75 patients with gastrointestinal stromal tumor were selected as the study subjects,and all the data were recorded by retrospective analysis.The clinical features,pathological data,immunohistochemical results and CT characteristics of gastrointestinal stromal tumors were analyzed.Results Among the 75 patients with gastrointestinal stromal tumor,68.00%(51/75)aged>50 years;42.67%(32/75)had abdominal pain and tenderness or swelling discomfort;34.67%(26/75)had symptoms such as black stools and gastrointestinal bleeding;and 22.67%(17/75)had an abdominal mass.The patients with abdominal tenderness accounted for 33.33%(25/75);abdominal mass was detected in 36.00%(27/75)of patients;mass was detected by intestinal examination in 10.67%(8/75)of patients;patients with no obvious clinical symptoms or positive signs accounted for 20.00%(15/75).After laboratory tests,it was confirmed that 20.00%(15/75)of the patients had decreased albumin or total protein,38.67%(29/75)of the patients had formation of occult blood in the stool routine,and 41.33%(31/75)of the patients had decreased hemoglobin.Among 75 patients with gastrointestinal stromal tumors,10.67%(8/75)were pathologically graded as very low risk,22.67%(17/75)as low risk,24.00%(18/75)as intermediate risk,and 42.67%(32/75)as high risk.The cell morphology and histological features of gastrointestinal stromal tumor were characterized as spindle-shaped or epithelioid.In 75 patients with gastrointestinal stromal tumors,CD117 was positively expressed in up to 94.67%of patients,and CD34 was positively expressed in up to 72.00%of patients and some patients had positive expression of neuron-specific enolase(NSE),smooth muscle actin(SMA),S-100,and PGP915.Among the 75 patients with gastrointestinal stromal tumors,59 patients had CT findings of distended growth,presenting as ellipsoidal or spherical masses,and 28 patients showed lobulated CT morphology.Among the 34 patients,2
作者
程倩
CHENG Qian(Department of Pathology,Tieling Central Hospital,Tieling 112000,China)
出处
《中国现代药物应用》
2024年第3期54-57,共4页
Chinese Journal of Modern Drug Application
关键词
胃肠道间质瘤
病理学诊断
CT检查
病理特点
Gastrointestinal stromal tumors
Pathological diagnosis
CT examination
Pathological characteristics