摘要
目的研究缝线类型对胃十二指肠溃疡穿孔患者微创修补术治疗效果的影响。方法选取胃十二指肠溃疡穿孔患者78例,采用随机数字表法分为观察组和对照组,每组39例。两组均行微创修补术治疗,观察组采用2-0聚乙醇酸可吸收手术缝线,对照组采用2-0普通丝线。比较两组溃疡愈合率、手术指标和临床指标、术后疼痛程度、肠道屏障功能、并发症发生率及生活质量。结果观察组溃疡愈合率为97.44%,对照组为74.36%,两组溃疡愈合率比较差异有统计学意义(P<0.05)。观察组术后疼痛程度1级17例,2级19例,3级2例,4级1例;对照组术后疼痛程度1级9例,2级18例,3级8例,4级4例。两组术后疼痛程度比较差异有统计学意义(P<0.05)。观察组并发症发生率为2.56%,低于对照组的20.51%,差异有统计学意义(P<0.05)。观察组手术时间与对照组比较,差异无统计学意义(P>0.05)。观察组下床时间、肠道功能恢复时间、住院时间分别为(2.26±0.76)、(2.54±0.97)、(6.56±1.31)d,短于对照组的(2.85±1.01)、(3.18±1.15)、(7.19±1.47)d(P<0.05)。术后3 d,观察组血清二胺氧化酶(DAO)(118.42±8.46)U/ml、D-乳酸(D-Lac)(23.19±2.08)μg/ml低于对照组的(139.53±9.85)U/ml、(29.47±2.77)μg/ml(P<0.05)。术后8周,观察组胃肠道生活质量指数(GIQLI)评分(125.45±9.65)分高于对照组的(107.91±8.37)分(P<0.05)。结论聚乙醇酸可吸收手术缝线在胃十二指肠溃疡穿孔微创修补术中的使用能够促进溃疡愈合,改善患者生活质量,降低术后并发症风险,且对肠道屏障功能的影响较小。
Objective To study the effect of suture type on the therapeutic effect of minimally invasive repair surgery for patients with perforation of gastroduodenal ulcer.Methods A total of 78 patients with perforation of gastroduodenal ulcer were selected,and were randomly divided into an observation group and a control group using a random number table method,with 39 cases in each group.Both groups underwent minimally invasive surgical repair,with 2-0 polyglycolic acid absorbable surgical suture used in the observation group,and 2-0 ordinary silk thread in the control group.The ulcer healing rate,surgical and clinical indicators,postoperative pain intensity,intestinal barrier function,incidence of complications,and quality of life between two groups.Results The ulcer healing rate was 97.44%in the observation group and 74.36%in the control group,and the difference in ulcer healing rates between the two groups was statistically significant(P<0.05).The postoperative pain intensity in the observation group was grade 1 in 17 cases,grade 2 in 19 cases,grade 3 in 2 cases,and grade 4 in 1 case;the postoperative pain intensity in the control group was grade 1 in 9 cases,grade 2 in 18 cases,grade 3 in 8 cases,and grade 4 in 4 cases.There was significant difference in postoperative pain intensity between the two groups(P<0.05).The incidence of complications in the observation group was 2.56%,which was lower than 20.51%in the control group,and the difference was statistically significant(P<0.05).The operation time of the observation group was not significantly different from that of the control group(P>0.05).The time of getting out of bed,time for intestinal function recovery and length of hospital stay in the observation group were(2.26±0.76),(2.54±0.97)and(6.56±1.31)d,which were shorter than(2.85±1.01),(3.18±1.15)and(7.19±1.47)d in the control group(P<0.05).At 3 d after surgery,the serum diamine oxidase(DAO)in the observation group was(118.42±8.46)U/ml and the D-lactic acid(D-Lac)was(23.19±2.08)μg/ml,which were lower tha
作者
赵东峰
李厚敏
周庆亮
ZHAO Dong-feng;LI Hou-min;ZHOU Qing-liang(Department One of General Surgery,Peixian County People's Hospital,Xuzhou 221600,China)
出处
《中国现代药物应用》
2024年第3期6-10,共5页
Chinese Journal of Modern Drug Application
关键词
胃十二指肠溃疡穿孔
缝线类型
聚乙醇酸可吸收手术缝线
微创修补术
Perforation of gastroduodenal ulcer
Suture type
Polyglycolic acid absorbable surgical suture
Minimally invasive repair surgery
