摘要
铁死亡(ferroptosis)是Dixon等人在2012年首次提出的一种新的细胞程序性死亡方式,它以细胞内铁水平过载和氧化性损伤为主要特征。衰老(aging)是由多种因素共同导致的不可避免的一种生理功能逐渐退化的过程,随着细胞衰老的进行,机体组织器官的生理功能会出现渐进性紊乱和衰退,从而增加机体患病和死亡的风险,例如,神经退行性疾病、癌症和心血管疾病等。目前,已经陆续有学者发现铁死亡与衰老之间存在千丝万缕的联系,特定类型的细胞衰老以及衰老相关疾病有时会伴随着细胞铁死亡的相关特征。但是,铁死亡与衰老之间是否存在因果关系,目前并未定论。本文综述了铁死亡与衰老的特点,并对两者之间的共有特征进行总结,例如,DNA损伤、氧化还原稳态失衡和线粒体功能障碍等。另外,本文还讨论了铁死亡与部分衰老相关疾病的联系,包括帕金森症、阿尔茨海默症,以及部分癌症。本文通过对铁死亡和衰老两个领域之间潜在的联系进行分析和总结,可以为铁死亡与衰老的基础性研究提供新的视角,进而为相关临床疾病的治疗提供有价值的线索。
Ferroptosis is a novel programmed cell death pathway,which was first proposed by Dixon in 2012.It is characterized by intracellular iron overload and oxidative damage.Aging is an inevitable process characterized by the gradual deterioration of various physiological functions,which results from multiple factors.During the aging process,physiological functions of tissues and organs become dysregulated and deteriorated,leading to increase drisk of disease and death,such as neurodegenerative diseases,cancer and cardiovascular diseases.Recently,some studies have shown that there is an inextricable link between ferroptosis and aging.Aging processes of certain cell lines and age-related diseases exhibit some properties of ferroptosis.However,it remains unclear whether there is a causal relationship between ferroptosis and aging.In this review,we summarize the features of ferroptosis and aging,and point out the common characteristics in ferroptosis and aging,such as DNA damage,redox homeostasis imbalance,mitochondrial dysfunction and so on.In addition,this review discusses the relationship between ferroptosis and some age-related diseases,including Parkinson’s disease,Alzheimer’s disease,and some types of cancers.This review summarizes the potential link between ferroptosis and aging,provides a novel perspective on the fundamental research on ferroptosis and aging,aiming for valuable insights in the treatment of related diseases.
作者
管文斌
刘新光
赵炜
GUAN Wen-Bin;LIU Xin-Guang;ZHAO Wei(School of Medical Technology,Guangdong Medical University,Dongguan 523808,Guangdong,China;Guangdong Provincial Key Laboratory of Medical Molecular Diagnosis,Dongguan 523808,Guangdong,China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2024年第1期28-37,共10页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金项目(No.31701050)
广东省自然科学基金项目(No.2018A0303070020)资助。
关键词
衰老
铁死亡
衰老因素
衰老相关疾病
aging
ferroptosis
aging factors
age-related diseases
