摘要
多囊卵巢综合征(PCOS)是一种复杂的异质性内分泌疾病,育龄妇女发病率约为5%~18%,但病因和病理生理仍不清楚。PCOS是无排卵性不孕症最常见的病因,接受体外受精-胚胎移植(IVF-ET)的PCOS患者常存在卵巢过度刺激综合征发生率高、受精率低、流产率高等问题。卵泡液代谢物可为各个阶段的卵母细胞提供养分,小分子代谢物改变会严重影响卵母细胞的生长以及胚胎发育潜能。本文就PCOS患者卵泡液中的各类代谢物进行综述,以期为研究PCOS患者卵母细胞发育潜能低下的发病机制以及寻找更有效的药物作用靶点提供有效证据。
Polycystic ovary syndrome(PCOS)is a complex and heterogeneous endocrine disorder that affects 5%-18%of women of reproductive age,while the etiology and pathophysiology of PCOS are still not completely understood.PCOS is the most common cause of anovulatory infertility and PCOS patients are prone to develop ovarian hyperstimulation syndrome,low fertilization rates,and high abortion rates during in vitro fertilization-embryo transfer(IVF-ET).Follicular fluid metabolites provide nutrients for oocytes at all stages,and changes in small molecule metabolites will seriously affect the growth of oocytes and the developmental potential of embryos.This article reviews the metabolites in follicular fluid of patients with PCOS,in order to provide evidences for exploring the pathogenesis of low oocyte developmental potential in patients with PCOS and finding more effective drug targets.
作者
余佳月
尹太郎
杨菁
YU Jia-yue;YIN Tai-lang;YANG Jing(Reproductive Medical Center,Renmin Hospital of Wuhan University,Hubei Clinical Research Center for Assisted Reproductive Technology&Embryonic Development,Wuhan 430060)
出处
《生殖医学杂志》
CAS
2024年第2期265-270,共6页
Journal of Reproductive Medicine
基金
国家自然科学基金(81971356)。
关键词
多囊卵巢综合征
卵泡液
代谢组学
体外受精-胚胎移植
Polycystic ovary syndrome
Follicular fluid
Metabolomics
In vitro fertilization-embryo transfer
