摘要
目的探讨幽门螺杆菌(Hp)感染与溃疡性结肠炎患者血清胃肠激素、单胺类神经递质水平的关系。方法将初诊溃疡性结肠炎患者145例作为研究组,另选取同期行胃肠镜检查无异常人群140名作为对照组。2组均采用13C-尿素呼气试验(13C-UBT)检测Hp感染情况,并检测胃肠激素[P物质(SP)、内皮素(ET)、血管活性肠肽(VIP)]和单胺类神经递质[去甲肾上腺素(NE)、5-羟色胺(5-HT)]水平。比较研究组中活动期和缓解期患者血清胃肠激素、单胺类神经递质水平,另比较Hp阳性和阴性患者血清胃肠激素、单胺类神经递质水平,并应用Logistic回归分析法分析溃疡性结肠炎患者Hp感染与胃肠激素和单胺类神经递质相关指标的关系。结果研究组Hp感染率和VIP水平低于对照组(P<0.05),SP、ET、NE、5-HT水平均高于对照组(P均<0.05)。活动期组患者Hp感染率和VIP水平低于缓解期组(P<0.05),SP、ET、NE、5-HT水平均高于缓解期组患者(P均<0.05)。研究组中Hp阳性患者SP、ET、NE、5-HT水平均低于Hp阴性患者(P均<0.05),VIP水平高于Hp阴性患者(P<0.05)。Logistic回归分析结果显示,SP、ET、NE、5-HT水平升高均是溃疡性结肠炎患者Hp感染的保护因素(P均<0.05),VIP水平升高则是危险因素(P<0.05)。结论在溃疡性结肠炎中,Hp感染和未感染患者胃肠激素与单胺类神经递质水平存在差异,Hp感染可能与患者胃肠激素和单胺类神经递质水平变化具有相关性。
Objective To investigate the relationship between Helicobacter pylori(Hp)infection and serum gastrointestinal hormones and monoamine neurotransmitter levels in patients with ulcerative colitis.Methods 145 patients newly diagnosed with ulcerative colitis were selected into the study group,and 140 patients without abnormal results by gastrointestinal endoscopy were assigned into the control group.In two groups,Hp infection was diagnosed by using 13C urea breath test(13C-UBT).The levels of gastrointestinal hormones(substance P(SP),endothelin(ET),vasoactive intestinal peptide(VIP))and monoamine neurotransmitters(norepinephrine(NE),5-hydroxytryptamine(5-HT))were detected.Serum levels of gastrointestinal hormones and monoamine neurotransmitters were compared between active and remission phase patients in the study group.Serum levels of gastrointestinal hormones and monoamine neurotransmitters were compared between Hp-positive and-negative patients.The relationship between Hp infection and gastrointestinal hormone-and monoamine neurotransmitter-related indexes in patients with ulcerative colitis was assessed by Logistic regression analysis.Results Hp infection rate and VIP level in the study group were lower,whereas the levels of SP,ET,NE,and 5-HT were higher than those in the control group(all P<0.05).Hp infection rate and VIP level in the active phase group were lower,while the levels of SP,ET,NE,and 5-HT were higher than those in the remission phase group(all P<0.05).In the study group,the levels of SP,ET,NE and 5-HT in Hp-positive patients were lower,whereas the level of VIP was higher compared with those in Hp-negative counterparts(all P<0.05).Logistic regression analysis showed that SP,ET,NE and 5-HT were the protective factors for Hp infection in patients with ulcerative colitis(all P<0.05),while elevated level of VIP was the risk factor(P<0.05).Conclusions In ulcerative colitis patients,there are differences in the levels of gastrointestinal hormones and monoamine neurotransmitters between patients with and with
作者
王瑞雪
张峰
张强
Wang Ruixue;Zhang Feng;Zhang Qiang(Department of Medical Laboratory,Jinan Integrated Hospital of Traditional Chinese and Western Medicine,Ji’nan 271100,China)
出处
《新医学》
CAS
2024年第2期122-126,共5页
Journal of New Medicine
基金
山东省中医药科技项目(Q-2022003)。
关键词
幽门螺杆菌感染
溃疡性结肠炎
P物质
内皮素
血管活性肠肽
去甲肾上腺素
5-羟色胺
Helicobacter pylori infection
Ulcerative colitis
Substance P
Endothelin
Vasoactive intestinal peptide
Norepinephrine
5-hydroxytryptamine
