摘要
目的分析高通量血液透析在尿毒症继发性甲状旁腺功能亢进(SHPT)患者中的应用效果。方法选取2018年6月至2020年6月在本院行血液透析的64例尿毒症合并SHPT患者,随机将其分为试验组和对照组,每组各32例。试验组接受高通量血液透析,对照组接受低通量血液透析;对比两组治疗前以及治疗3、6、9、12个月后的血钙、血磷、甲状旁腺激素(iPTH)、骨型碱性磷酸酶及碱性磷酸酶水平,比较两组的生存率。结果透析后的两组患者各个时间段的血磷、iPTH以及骨型碱性磷酸酶水平均明显优于透析前(均P<0.05),且试验组在各个时间段的血磷、iPTH、骨型碱性磷酸酶水平显著优于对照组,差异均有统计学意义(均P<0.05)。血钙水平与iPTH水平呈正相关(r=0.931,P=0.023),血磷、骨型碱性磷酸酶水平与iPTH水平均呈负相关(r=-1.654、-0.796,P<0.05)。血钙、血磷、骨型碱性磷酸酶均是iPTH水平的影响因素(均P<0.05)。试验组患者的生存率显著高于对照组(P<0.05)。结论高通量血液透析可有效降低血磷水平及骨型碱性磷酸酶水平,进而可有效控制iPTH水平。
Objective To analyze the effect of high-flux hemodialysis in uremic patients with secondary hyperparathyroidism(SHPT).Methods From June 2018 to June 2020,64 uremic patients with secondary SHPT who underwent hemodialysis in our hospital were selected and randomly divided into experimental group and control group,with 32 cases in each group.The experimental group received high-flux hemodialysis and the control group received low-flux hemodialysis.The serum calcium,phosphorus,parathyroid hormone(iPTH),bone alkaline phosphatase before treatment and 3,6,9,12 months after treatment were compared between the two groups.And alkaline phosphatase levels,and the survival rates of the two groups were compared.Results The levels of blood phosphorus,iPTH and bone alkaline phosphatase in each time period after dialysis in both groups were significantly better than those before dialysis(all P<0.05),and the levels of blood phosphorus,iPTH and bone alkaline phosphatase in the experimental group were significantly better than those in the control group at each time period,with a statistically significant difference(all P<0.05).Serum calcium was positively correlated with iPTH(r=0.931,P=0.023),while serum phosphorus and bone alkaline phosphatase were negatively correlated with iPTH(r=-1.654,-0.796,P<0.05).Blood calcium,phosphorus and bone alkaline phosphatase were the influencing factors of iPTH(all P<0.05).The survival rate of the experimental group was significantly higher than that of the control group(P<0.05).Conclusions High-flux hemodialysis can effectively reduce blood phosphorus level and bone alkaline phosphatase level,and then effectively control the level of iPTH.
作者
谭文
何红梅
蒲跃
宋娇
陈艳琼
Tan Wen;He Hongmei;Pu Yue;Song Jiao;Chen Yanqiong(Department of Internal Medicine,Nanchong Hospital of Traditional Chinese Medicine,Nanchong 637000,China;Department of Acupuncture and Rehabilitation,Nanchong Hospital of Traditional Chinese Medicine,Nanchong 637000,China;Department of Surgery,Nanchong Hospital of Traditional Chinese Medicine,Nanchong 637000,China)
出处
《国际泌尿系统杂志》
2024年第1期134-138,共5页
International Journal of Urology and Nephrology
基金
南充市研发资金项目(19YFZJ0005)。
