摘要
脓毒症引起的急性肺损伤是一种发病机制复杂、治疗成本昂贵、致死率高的脏器疾病。近年来,中医药在脓毒症及其并发症治疗中的应用日益增多,强调发挥多组分、多途径、多靶点的特点来平衡免疫反应,促进血液循环,达到扶正固本之效。中药单体及其有效成分通过发挥清热解毒、通腑下热、活血化瘀和扶正固本的功效,以降低氧化应激、抑制炎症通路和调节免疫反应,从而达到治疗脓毒症急性肺损伤的作用。综述中药单体及有效成分对脓毒症急性肺损伤的作用机制和疗效研究进展,期望为中医药治疗脓毒症及其并发症提供理论基础和经验支持。
Acute lung injury caused by sepsis is an organ disease characterized by complex pathogenesis,high treatment costs and high mortality rates.In recent years,the application of traditional Chinese medicine(TCM)has been increasing in the treatment of sepsis and its complications.TCM emphasizes the utilization of its characteristics such as multiple components,pathways,and targets to balance immune responses,promote blood circulation,and achieve the effect of strengthening and consolidating body resistance.TCM monomers and their active ingredients can reduce oxidative stress levels,inhibit inflammatory pathways,and regulate immune responses by exerting the effects of clearing heat and removing toxicity,freeing the bowels and eliminating heat,activating blood and resolving stasis,and strengthening and consolidating body resistance,in order to achieve the effect of treating acute lung injury caused by sepsis.This paper reviews the research progress in the mechanisms and therapeutic effect of TCM monomers and active ingredients in the treatment of acute lung injury caused by sepsis,in order to provide theoretical basis and empirical support for the treatment of sepsis and its complications with TCM.
作者
付晨菲
梁群
李建龙
FU Chenfei;LIANG Qun;LI Jianlong(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《长春中医药大学学报》
2024年第2期219-225,共7页
Journal of Changchun University of Chinese Medicine
基金
国家自然科学基金面上项目(81974557)
黑龙江省“双一流”学科协同创新成果建设项目(LJGXCG2022-097)。
关键词
中药单体
中药有效成分
脓毒症
急性肺损伤
traditional Chinese medicine monomer
active ingredients of traditional Chinese medicine
sepsis
acute lung injury
