摘要
慢性疼痛全球患病率超过30%,现已成为严重的公共卫生问题。因其产生及维持的病理生理学机制复杂,目前临床治疗效果欠佳,给病人带来了极大困扰。维生素D是一种人体必需的脂溶性维生素,现也被认为是一种多效性神经类固醇。研究表明维生素D可以有效缓解慢性疼痛,但目前维生素D对于慢性疼痛的调控机制尚未完全明确。本文将就维生素D调控慢性疼痛及其相关机制进行综述,以期为疼痛提供新的治疗思路。
Chronic pain,affecting over 30%of the global population,has emerged as a significant public health concern.Due to the complex pathophysiological mechanisms involved in its generation and maintenance,the effect of current clinical treatment is unsatisfactory,leading to considerable distress to patients.Vitamin D,is an essential fat soluble vitamin for the human body,and is now also considered a multifunctional neurosteroid.Research has shown that vitamin D can effectively alleviate chronic pain,but the regulatory mechanism of vitamin D on chronic pain is not yet fully understood.This article will provide a review on the regulation of chronic pain by vitamin D and its related mechanisms,offering novel therapeutic insights for pain.
作者
杨济玮
尤浩军
雷静
YANG Ji-wei;YOU Hao-jun;LEI Jing(Center for Translational Medicine Research on Sensory-Motor Diseases,Yan'an University,Yan'an 716000,China;Key Laboratory of Yan'an Sports Rehabilitation Medicine,Yan'an 716000,China)
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2024年第2期125-130,共6页
Chinese Journal of Pain Medicine
基金
国家自然科学基金(81860410,82074564)。
