摘要
目的 分析甲状腺肿瘤患者病理组织学与血清炎症因子、凝血指标的相关性。方法 选择2021年3月至9月甲状腺癌患者45例为甲状腺癌组,分为乳头状癌组(n=32)、滤泡癌组(n=13),有淋巴结转移组(n=11)、淋巴结未转移组(n=34);同期选择健康对照组60名(甲状腺超声评价分级1级)、甲状腺结节组56例(甲状腺超声评价分级2~3级)作为对照。采集3组受检者静脉血,检测血常规,计算系统免疫炎症指数(SII),检测趋化因子受体4(CXCR4)蛋白、肿瘤坏死因子-α(TNF-α)、高迁移率族蛋白B1(HMGB1)水平,检测活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(Fbg)水平。结果 血清SII、HMGB1、TNF-α、CXCR4水平在健康对照组、甲状腺结节组、甲状腺癌组患者逐渐升高,3组比较差异具有统计学意义(P<0.05)。血清Fbg、TT水平在健康对照组、甲状腺结节组、甲状腺癌组患者逐渐升高,PT、APTT水平逐渐降低,3组比较差异具有统计学意义(P<0.05)。滤泡癌组患者血清SII、HMGB1、TNF-α、CXCR4水平明显高于乳头状癌组,淋巴结转移组患者血清SII、HMGB1、TNF-α、CXCR4水平明显高于淋巴结未转移组(P<0.05)。滤泡癌组患者血清Fbg、TT水平明显高于乳头状癌组,PT、APTT水平明显低于乳头状癌组,淋巴结转移组患者血清Fbg、TT水平明显高于淋巴结未转移组,PT、APTT水平明显低于淋巴结未转移组(P<0.05)。Pearson相关性分析显示,SII、HMGB1、TNF-α、CXCR4、Fbg、TT与滤泡癌、淋巴结转移呈明显正相关,PT、APTT与滤泡癌、淋巴结转移呈明显负相关(P均<0.05)。结论甲状腺癌可出现炎症反应及凝血功能异常,且炎症因子、凝血指标与病理类型、淋巴结转移存在明显相关性,检测其表达水平对诊断甲状腺癌及评估病情变化有一定帮助。
Objective To analyze the correlation between histopathology and serum inflammatory factors and coagulation indexes in patients with thyroid tumors.Methods Forty-five patients with thyroid cancer from March 2021 to September 2021 were selected as thyroid cancer group,which were divided into papillary cancer group(n=32),follicular cancer group(n=13),lymph node metastasis group(n=11)and lymph node non-metastasis group(n=34).At the same time,60 healthy controls(grade 1 of thyroid ultrasound evaluation)and thyroid gland(n=56)were selected.The venous blood of three groups were collected,blood routine was detected,systemic immune inflammatory index(SII)was calculated,the levels of chemokine receptor 4(CXCR4)protein,tumor necrosis factor-α(TNF-α)and high mobility group protein B1(HMGB1)were detected,and active partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen were detected.Results The levels of serum SII,HMGBl,TNF-αand CXCR4 increased gradually in healthy control group,thyroid nodule group and thyroid cancer group,and the difference among the three groups was statistically significant(P<0.05).The levels of serum Fbg and TT increased gradually in healthy control group,thyroid nodule group and thyroid cancer group,while the levels of PT and aPTT decreased gradually.The difference among the three groups was statistically significant(P<0.05).The levels of serum SII,HMGB1,TNF-αand CXCR4 in follicular carcinoma group were significantly higher than those in papillary carcinoma group,and the levels of serum SII,HMGB1,TNF-αand CXCR4 in lymph node metastasis group were significantly higher than those in lymph node non-metastasis group(P<0.05).The levels of serum Fbg and TT in follicular carcinoma group were significantly higher than those in papillary carcinoma group,and the levels of PT and APTT were significantly lower than those in papillary carcinoma group.The levels of serum Fbg and TT in lymph node metastasis group were significantly higher than those in lymph node non-metastasis group,
作者
程卫
戚新春
Cheng Wei;Qi Xinchun(Department of Head and Neck,Shaanxi Cancer Hospital,Xi'an 710061,China)
出处
《山西医药杂志》
CAS
2023年第24期1849-1853,共5页
Shanxi Medical Journal
关键词
甲状腺肿瘤
病理类型
淋巴结转移
炎症因子
凝血
相关性
Thyroid tumor
Pathological type
Lymph node metastasis
Inflammatory factors
Coagulation
correlation
