摘要
目的 探讨s全麻剖宫产患者应用艾司氯胺酮对其术后痛觉过敏的作用效果,以期为全麻剖宫产患者提供有效的干预方案。方法 选择2021年1月至2023年12月收治的全麻剖宫产患者82例,以单双数字法将其分为试验组和对照组,每组41例。2组均开展全麻剖宫产,试验组于硬膜外阻滞完成后静脉注射少量的艾司氯胺酮;对照组于硬膜外阻滞完成后静脉注射等量的0.9%氯化钠溶液。对比2组前臂、切口周围痛阈,苏醒时间、拔管时间、镇痛药用量以及按压次数,不良反应。结果 试验组术后6 h、12 h以及24 h时的前臂周围痛阈高于对照组(均P<0.05)。试验组术后6 h、12 h以及24 h时的切口周围痛阈高于对照组(均P<0.05)。试验组镇痛药用量以及按压次数低于对照组(均P<0.05)。2组恶心呕吐、头晕以及瘙痒发生率差异无统计学意义(P>0.05)。结论 全麻剖宫产患者应用艾司氯胺酮可显著改善术后痛觉过敏情况,且不会增加不良反应发生风险,值得推广应用。
Objective To study the effect of esketamine on postoperative hyperalgesia in patients with caesarean section under general anesthesia,thus providing an effective intervention scheme for patients with caesarean section under general anesthesia.Methods A total of 82 patients with cesarean section under general anesthesia admitted to the hospital from January 2021 to December 2023 were selected.They were divided into experimental group(41 cases) and control group(41 cases) by single and double digit method.Patients in both groups underwent cesarean section under general anesthesia,and those in the experimental group were given a small amount of esketamine intravenously after epidural block.Patients in the control group received the same amount of normal saline intravenously after epidural block.The pain threshold in the forearm and the incision,recovery time,extubation time,dosage of analgesics,number of compressions,and the adverse events were compared between the two groups.Results The pain thresholds of experimental group around the forearm at 6h,12h and 24h were significantly higher than those of control group(all P<0.05).The pain threshold in the incision of experimental group at 6h,12h and 24h were significantly higher than those of control group(all P<0.05).The dosage of analgesic and times of compression in the experimental group were significantly lower than those of the control group(both P<0.05).There was no significant difference in the incidence of nausea,vomiting,dizziness and pruritus between the two groups(P>0.05).Conclusion Esketamine can significantly improve postoperative hypersensitivity without increasing the risk of adverse events in patients with caesarean section under general anesthesia,and it is worthy of popularization and application.
作者
宋建敏
刘正来
敖利
白耀武
SONG Jianmin;LIU Zhenglai;AO Li(Department of Anesthesiology,Tangshan Maternal and Child Health Hospital,Hebei,Tangshan 063000,China)
出处
《河北医药》
CAS
2024年第1期109-111,共3页
Hebei Medical Journal
基金
河北省医学科学研究课题(编号:20221752)。
关键词
全麻剖宫产
艾司氯胺酮
痛觉过敏
不良反应
治疗结果
cesarean section under general anesthesia
esketamine
hyperalgesia
adverse reactions
treatment outcome