摘要
目的:探讨晚期早产儿(胎龄34周至36^(+6)周)新生儿呼吸窘迫综合征(NRDS)合并新生儿急性呼吸窘迫综合征(ARDS)的高危因素。方法:回顾性分析2019年9月至2023年1月某院新生儿重症监护病房住院治疗的晚期早产儿NRDS病例为研究对象。根据是否发生ARDS分为观察组(NRDS合并ARDS组)和对照组(单纯NRDS组),对两组的围产期高危因素进行对比分析。结果:研究对象共92例,其中观察组44例、对照组48例。两组在性别、胎龄、体重、分娩方式的差异无统计学意义(P>0.05)。观察组妊娠晚期呼吸道感染、妊娠晚期阴道炎、妊娠晚期维生素D缺乏、羊水粪染、窒息发生率高于对照组,差异具有统计学意义(P<0.05)。两组妊娠期糖尿病、妊娠期高血压、产前促肺治疗、胎膜早破、脐带缠绕、前置胎盘、胎盘早剥、低体重、宫内窘迫的发生率无统计学意义(P>0.05)。将单因素分析中有统计学意义的变量(妊娠晚期呼吸道感染、妊娠晚期阴道炎、妊娠晚期维生素D缺乏、羊水粪染、窒息)纳入到Logistics回归分析中,经逐步Logistics回归分析妊娠晚期呼吸道感染(OR=9.613,95%CI 1.056-87.489,P<0.05);妊娠晚期阴道炎(OR=11.469,95%CI 1.286-102.294,P<0.05);妊娠晚期维生素D缺乏具有统计学意义(OR=7.499,95%CI 1.887-29.802,P<0.05),与晚期早产儿NRDS合并ARDS的关联均有统计学意义。结论:妊娠晚期呼吸道感染、妊娠晚期阴道炎、妊娠晚期维生素D缺乏是晚期早产儿NRDS合并ARDS的独立危险因素。
Objective:To investigate the perinatal risk factors for late preterm neonatal respiratory distress syndrome(NRDS)with acute respiratory distress syndrome(ARDS).Methods:A retrospective analysis was conducted on cases of late preterm NRDS admitted to the neonatal intensive care unit of a certain hospital from September 2019 to January 2023.The patients were divided into the observation group(NRDS with ARDS)and the control group(simple NRDS)according to whether or not they developed ARDS.The perinatal risk factors of the two groups were compared.Results:A total of 92 cases were included,with 44 cases in the observation group and 48 cases in the control group.There were no significant differences in sex,gestational age,body weight,and mode of delivery between the two groups(P>0.05).The incidence of late-term respiratory tract infection,late-term vaginitis,late-term vitamin D deficiency,meconium-stained amniotic fluid,and asphyxia was higher in the observation group than in the control group,with statistically significant differences(P<0.05).The incidence rates of gestational diabetes,gestational hypertension,prenatal lung stimulation therapy,premature rupture of membranes,umbilical cord entanglement,placenta previa,placental abruption,low body weight,and intrauterine distress revealed no statistical significance in both groups(P>0.05).The variables with statistical significance in the univariate analysis(late-term respiratory tract infection,late-term vaginitis,late-term vitamin D deficiency,meconium-stained amniotic fluid,and asphyxia)were included in the logistic regression analysis.The results of the stepwise logistic regression analysis showed that late-term respiratory tract infection(OR=9.613,95%CI 1.056-87.489,P<0.05),late-term vaginitis(OR=11.469,95%CI 1.286-102.294,P<0.05),and late-term vitamin D deficiency(OR=7.499,95%CI 1.887-29.802,P<0.05)were all statistically significant,and were associated with late preterm NRDS with ARDS.Conclusion:Late-term respiratory tract infection,late-term vaginitis,and late-ter
作者
黄凤珍
王丽君
郭春艳
祁宏亮
周启立
HUANG Fengzhen(The Affiliated Hospital of Chengde Medical University,Hebei Chengde 067000,China)
出处
《河北医学》
CAS
2024年第2期322-325,共4页
Hebei Medicine
基金
河北省医学科学研究重点课题指令性计划项目,(编号:20160017)。
