摘要
目的:收集某精神专科医院160例药品不良反应(ADR)报告并分析ADR的发生规律、特点和影响因素,探讨影响ADR严重程度的因素,为临床合理用药提供依据。方法:回顾性分析该院2020年上报的160例ADR报告。收集患者一般资料,根据患者ADR严重程度分为一般ADR组和严重ADR组。通过单因素及多因素Logistic回归分析,筛选影响精神科患者ADR严重程度的高危因素。结果:单因素分析结果表明,性别、年龄、药品类别、给药途径、报告者、关联性评价以及累及系统/器官等指标与ADR严重程度相关。多因素Logistic回归分析结果显示,女性、≥50岁、可能有关、3种及以上、口服、医生、心血管系统疾病、皮肤疾病与ADR严重程度之间存在相关性(P<0.05)。结论:临床诊治中应实时监测ADR,控制用药风险,以降低严重ADR发生率,减少药害事件,保障患者用药安全。
Objective:To analyze the patterns,characteristics,and influencing factors of 160 cases of adverse drug reaction(ADR)in a certain psychiatric hospital,explore the factors that affect the severity of ADRs,and provide a basis for rational drug use in clinical practice.Methods:A retrospective analysis was conducted on 160 ADR reports from the hospital in 2020.Collect general information of patients and divide them into general ADR group and severe ADR group based on the severity of ADR.High-risk factors related to the severity of ADR in psychiatric patients were screened through univariate and multivariate logistic regression analysis.Results:Univariate analysis found that gender,age,drug type,route of administration,rapporteur,causal relationship,and involvement of systems/organs were correlated with the severity of ADR.The results of multivariate logistic regression analysis showed a significant correlation(P<0.05)between female,age≥50 years old,possibly related,combination therapy with more than 3 drugs,oral administration,physician report,involvement of cardiovascular system diseases,and skin diseases with the severity of ADR.Conclusion:Real time ADR monitoring should be carried out in clinical diagnosis and treatment to control medication risks,reduce the incidence of severe ADR,and ensure patient medication safety.
作者
刘伟杰
钱东丽
陈永新
张瑞岭
LIU Wei-jie;QIAN Dong-li;CHEN Yong-xin;ZHANG Rui-ling(Department of Pharmacy,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,China;Psychiatric,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,China)
出处
《中国合理用药探索》
CAS
2024年第1期92-97,共6页
Chinese Journal of Rational Drug Use
基金
河南省高校科技创新团队支持计划(17IRTSTHN023)
河南省卫生计生科技创新型人才“51282”工程。
关键词
精神科
药品不良反应
合理用药
严重程度
影响因素
psychiatry
adverse drug reactions
rational use of drugs
severity
influencing factor
