摘要
目的:探讨益气复脉汤加减联合琥珀酸美托洛尔缓释片治疗气阴两虚证冠心病心律失常患者的临床疗效及安全性。方法:选取2020年1月—2022年12月驻马店市中医院就诊的80例冠心病心律失常患者作为研究对象,采用随机单盲法分为对照组和观察组,每组各40例。对照组采用琥珀酸美托洛尔缓释片治疗,观察组采用益气复脉汤加减联合琥珀酸美托洛尔缓释片治疗。比较两组患者临床疗效、中医症候评分、血脂指标水平、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评分、不良反应发生情况。结果:观察组临床有效率高于对照组,差异有统计学意义(χ^(2)=4.114,P<0.05);治疗后,两组患者中医症候评分均较治疗前下降,观察组中医症候评分均低于对照组,差异有统计学意义(t=15.171、11.068、9.319、8.485、6.869、7.153,P<0.05);治疗后,观察组血脂指标水平均低于对照组,差异有统计学意义(t=4.304、3.822、9.631、4.685,P<0.05);治疗后,观察组PSQI评分均低于对照组,差异有统计学意义(t=59.397、114.000、183.848、56.612、44.714、47.054、70.502、5.723,P<0.05)。结论:益气复脉汤加减联合琥珀酸美托洛尔缓释片可提高气阴两虚证冠心病心律失常患者临床疗效,缓解临床症状,降低血脂,改善生活质量,且不会增加不良反应的发生。
Objective:To investigate the clinical efficacy of the addition and subtraction of Yiqi Fuxin Tang combined with metoprolol succinate extended-release tablets in the treatment of arrhythmia in coronary heart disease with qi and yin deficiency.Methods:80 cases of coronary arrhythmia patients attending the hospital from January 2020 to December 2022 were selected as the study subjects,and were divided into the control group and the observation group using the randomized single-blind method,with 40 cases in each group.The control group was treated with metoprolol succinate extended-release tablets,and the observation group was treated with Yiqi Fuxin Tang Plus combined with metoprolol succinate extended-release tablets.The clinical efficacy,TCM symptom score,blood lipid index level,Pittsburgh Sleep Quality Index(PSQI)score,and the incidence of adverse reactions of patients in the two groups were counted.Results:The clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(χ^(2)=4.114,P<0.05).After treatment,the TCM symptom scores of both groups decreased compared with those before treatment,and the TCM symptom scores of the observation group were lower than those of the control group,and the difference was statistically significant(t=15.171,11.068,9.319,8.485,6.869,7.153,P<0.05).After treatment,the levels of lipid indexes in the observation group were lower than those in the control group,and the difference was statistically significant(t=4.304,3.822,9.631,4.685,P<0.05).After treatment,the PSQI scores of the observation group were lower than those of the control group,and the difference was statistically significant(t=59.397,114.000,183.848,56.612,44.714,47.054,70.502,5.723,P<0.05).Conclusion:The combination of Yiqi Fuxin Tang Plus Reduction and Metoprolol Succinate Delayed-Re-lease Tablets can improve the clinical efficacy of coronary heart disease arrhythmia in qi and yin deficiency,alleviate patients’clini-cal symptoms,reduce bloo
作者
侯明明
王鑫
李舒琪
Hou Mingming;Wang Xin;Li Shuqi(Heart Disease Ward 2,Zhumadian Hospital of Traditional Chinese Medicine,Zhumadian,Henan,463000,China)
出处
《黑龙江医学》
2024年第3期358-361,共4页
Heilongjiang Medical Journal
基金
河南省医学科技攻关计划(联合共建)项目(LHGJ20190779)。
关键词
益气复脉汤加减
琥珀酸美托洛尔缓释片
气阴两虚证
冠心病心律失常
临床疗效
生活质量
安全性
Yiqi Fumai Decoction
Metoprolol succinate sustained release tablets
Qi and Yin deficiency syndrome
Coronary heart disease arrhythmia
Clinical effect
Quality of life
Security
