摘要
目的 建立通宣理肺颗粒中紫苏叶挥发油掺伪桂皮油的高效液相色谱(HPLC)检查方法。方法 通过收集通宣理肺颗粒挥发油富集挥发性成分,并采用HPLC测定通宣理肺颗粒中桂皮醛。以十八烷基硅烷键合硅胶为填充剂;流动相为乙腈-水(35:65);检测波长:290 nm;柱温:35℃;流速:1.0 ml/min;进样量:10μl。结果97批次(83个生产批号,10家生产企业)通宣理肺颗粒中有42批次(41个生产批号,2家生产企业)检出桂皮醛。结论 此法对通宣理肺颗粒中掺伪桂皮醛有鉴别作用,方法专属性强,重复性好,为监管该中成药的质量起到了一定作用。
Objective To establish a method for the detection of perilla leaf volatile oil adulterated with cinnamon bark oil in Tongxuanlifei Granules.Methods The volatile components were enriched by collecting the volatile oil of Tongxuanlifei Granules,and cinnamaldehyde in Tongxuanlifei Granules was determined by HPLC.Octadecylsilane bonded silica gel was used as filler.The mobile phase was acetonitrile-water(35:65).The detection wavelength was 290 nm;The column temperature was 35℃;The flow rate was 1.0 ml/min;The injection volume was 10μl.Results Cinnamaldehyde was detected in 42 batches(41 production batch numbers,2 production enterprises)out of 97 batches(83 production batch numbers,10 production enterprises)of Tongxuanlifei Granules.Conclusion The method can identify the adulterated cinnamaldehyde in Tongxuanlifei Granules.It has strong specificity and good reproducibility,which plays a certain role in supervision of the quality of the Chinese patent medicine.
作者
曾军
谯明鸣
彭明红
刘学鹏
苏昱博
苗恬
鞠淼
周祥敏
ZENG Jun;QIAO Ming-ming;PENG Ming-hong;LIU Xue-peng;SU Yu-bo;MIAO Tian;JU Miao;ZHOU Xiang-min(Chongqing Institute for Food and Drug Control,Chongqing 401121,China;School of Pharmacy,Southwest University,Chongqing 400715,China;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《食品与药品》
CAS
2024年第1期63-66,共4页
Food and Drug
基金
重庆市药品科研项目(通宣理肺颗粒中桂皮醛检查项补充检验方法)。
