摘要
目的探讨Tis~T1期非小细胞肺癌(NSCLC)脏层胸膜受累情况与淋巴结转移的相关性。方法回顾性分析84例Tis~T1期NSCLC患者的临床资料。所有患者均行肺叶切除术+系统性淋巴结清扫术治疗,术后将病理标本送检,明确患者胸膜脏层浸润(VPI)状态,依据VPI分为分为PL0组与PL1/PL2组。收集两组患者年龄、性别、体质量指数、基础疾病、肿瘤大小、病理类型、肿瘤位置、脉管瘤栓、术前癌胚抗原(CEA)水平、基础疾病及淋巴结转移情况等资料。分析VPI与临床病理特征及淋巴结转移的关系。结果84例患者中18例合并VPI,脏层胸膜受累率为21.43%(18/84);PL1/PL2组肿瘤大小2~3 cm、术前CEA水平≥3.5 ng/L占比高于PL0组,差异有统计学意义(P<0.05);PL1/PL2组淋巴结转移率、N2比率高于PL0组,差异有统计学意义(P<0.05)。结论Tis~T1期NSCLC患者VPI与淋巴结转移存在密切关系,当合并VPI时则需考虑存在淋巴结转移,术中应予以广泛淋巴结清扫,避免术后复发转移。
Objective To investigate the correlation between visceral pleural involvement and lymph node metastasis in clinical Tis~T1 non-small cell lung cancer(NSCLC).Methods The clinical data of 84 patients with Tis~T1 stage NSCLC were retrospectively analyzed.All patients were treated with lobectomy+systematic lymph node dissection.After the operation,pathological specimens were sent for examination to determine the status of pleural visceral infiltration(VPI).According to VPI,the patients were divided into PL0 group and PL1/PL2 group.The data of age,sex,body mass index,basic disease,tumor size,pathological type,tumor location,vascular tumor thrombus,preoperative carcinoembryonic antigen(CEA),basic disease and lymph node metastasis were collected.The relationship between VPI and clinicopathological features and the relationship between VPI and lymph node metastasis were analyzed.Results Among the 84 patients,18 were complicated with VPI,and the incidence of visceral pleural involvement was 21.43%(18/84);The proportion of tumor size 2~3 cm and preoperative CEA level≥3.5 ng/l in PL1/PL2 group was higher than that in PL0 group(P<0.05);The lymph node metastasis rate and N2 rate in PL1/PL2 group were higher than those in PL0 group(P<0.05).Conclusion There is a close relationship between VPI and lymph node metastasis in patients with Tis~T1 stage NSCLC.When combined with VPI,lymph node metastasis should be considered.Extensive lymph node dissection should be performed during operation to avoid recurrence and metastasis after operation.
作者
刘博
许妍
栗文菊
罗执芬
LIU Bo;XU Yan;LI Wenju(Henan People's Hospital,Zhengzhou,450000)
出处
《实用癌症杂志》
2024年第2期241-243,258,共4页
The Practical Journal of Cancer
关键词
非小细胞肺癌
脏层胸膜受累
淋巴结转移
预后
Non-small cell lung cancer
Visceral pleura involvement
Lymph node metastasis
Prognosis
