摘要
【目的】应用集成磁共振成像技术(SyMRI)评估COVID-19康复患者脑灰质微结构的改变。【方法】29例COVID-19康复患者分为重症患者组(SG=11例)和普通患者组(OG=18例),选取年龄、性别、体质指数(BMI)和教育年限相匹配的健康志愿者作为健康对照组(HC=23例)。所有受试者均行SyMRI扫描,生成T1、T2定量图谱,利用自动解剖标记(AAL)模板将T1和T2图谱分割成90个感兴趣区(ROIs)。通过对ROI内的所有体素进行平均得到每个ROI的T1、T2弛豫值。分析比较三组间90个脑区的T1、T2值。【结果】HC相比,SG在双侧眶内额上回、双侧海马旁回、双侧豆状壳核、双侧颞中回、双侧颞下回、左侧眶部额上回、左侧眶部额下回、左侧直回、左侧前扣带与旁扣带脑回、右侧内侧和旁扣带脑回、左侧后扣带回、左侧缘上回的T2值显著升高(P<0.05);与OG相比,SG在左侧直回、左侧海马旁回、双侧颞中回、双侧颞下回的T2值显著升高(P<0.05)。与HC相比SG在双侧眶内额上回、左侧直回、左侧前扣带和旁扣带脑回、右侧后扣带回、左侧海马旁回、左侧舌回、左侧豆状壳核、左侧丘脑的T1值显著升高(P<0.05);与OG相比,SG在右侧后扣带回、右侧距状裂周围皮层、左侧豆状壳核的T1值显著升高(P<0.05)。【结论】COVID-19患者即使在康复后脑灰质微结构仍可能存在持续性或迟发性损伤,且损伤程度与病情严重程度相关;SyMRI可作为一项敏感的工具评估中枢神经系统(CNS)微结构损伤情况,有助于早期临床诊断。
【Objective】To assess the microstructural involvement of gray matter in recovered COVID-19 patients using Synthetic MRI.【Methods】This study was conducted in 29 recovered COVID-19 patients,including severe group(SG,n=11)and ordinary group(OG,n=18).Healthy volunteers matched by age,sex,BMI and years of education were selected as a healthy control group(HC=23 cases).Each subject underwent synthetic MRI to generate quantitative T1 and T2 maps,and the T1 and T2 maps were segmented into 90 regions of interest(ROIs)using automatic anatomical labeling(AAL)mapping.T1 and T2 values for each ROI were obtained by averaging all voxels within the ROIs.The T1 and T2 values of the 90 brain regions between the three groups were compared.【Results】Relative to HC,the SG had significantly higher T2 values in bilateral orbital superior frontal gyrus,bilateral parahippocampal gyrus,bilateral putamen,bilateral middle temporal gyrus,bilateral Inferior temporal gyrus,left orbital superior frontal gyrus,left orbital inferior frontal gyrus,left gyrus rectus,left anterior cingulate and paracingulate gyri,right median cingulate and paracingulate gyri,left posterior cingulate gyrus,and left supramarginal gyrus(P<0.05);Relative to OG,SG showed significantly increased T2 values in the left rectus gyrus,left parahippocampal gyrus,bilateral middle temporal gyrus,and bilateral inferior temporal gyrus(P<0.05).Relative to HC,the T1 values of SG were significantly increased in bilateral orbital superior frontal gyrus,left rectus gyrus,left anterior cingulate and paracingulate gyri,right posterior cingulate gyrus,left parahippocampal gyrus,left lingual gyrus,left putamen,left thalamus(P<0.05);Relative to OG,the T1 values of SG were significantly higher in the right posterior cingulate gyrus,right calcarine fissure and surrounding cortex,and left putamen(P<0.05).【Conclusions】Even after recovering from COVID-19,patients may still have persistent or delayed damage to their brain gray matter structure,which is correlated with the severity of
作者
谢青
吴文浩
廖健伟
王国杰
李绍林
张亚琴
XIE Qing;WU Wenhao;LIAO Jianwei;WANG Guojie;LI Shaolin;ZHANG Yaqin(Department of Radiology,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China)
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2024年第1期114-120,共7页
Journal of Sun Yat-Sen University:Medical Sciences
基金
国家自然科学基金(82371917)
广东省基础与应用基础研究基金(2020A1515010572)
珠海市基础与应用基础课题研究基金(ZH22017003200001PWC)。
