摘要
当归芍药散是出自张机《金匮要略》的一首经方,配伍经典、功效颇多,临床常用来治疗妇科疾病及其他多种疾病,疗效肯定,不良反应少。为使临床和实验中更好、更深入地研究当归芍药散,通过对当归芍药散的相关文献进行检索和整理,总结了其临床应用、药理作用机制及化学成分等方面的研究,发现该方不仅可以治疗慢性盆腔炎、卵巢囊肿、痛经、月经不调、乳腺疾病、妊娠高血压、不孕、围绝经期综合征等妇科疾病,对非酒精性脂肪肝、肾病综合征、心力衰竭、认知障碍、黄褐斑、风湿病等疾病也有很好的临床效果,无论与西药联用还是单独运用,临床效果均明显优于单纯西药治疗,而且很大程度上能纠正西药的不良反应。药理作用机制方面,经查阅文献整理发现当归芍药散具有抗炎、调节免疫、保护血管内皮、保护神经细胞、调控内分泌、调控脂代谢等药理作用。在总结中发现,目前对当归芍药散的研究较多,但某些相关疾病的临床报道较少,动物体内实验研究多而细胞层次研究较少,缺乏方中有效成分及药理作用探索研究且不够深入,以及与近年相关研究热点结合不够,这些都有待进一步研究和完善,为临床和实验研究提供科学依据。
Angelica Peony Powder is a prescription from ZHANG Zhongjing′s Golden Chamber Synopsis.It has classical compatibility and many effects and is clinically used to treat gynecological diseases and other diseases,with remarkable curative effects and fewer side effects.In order to better and deeply study Angelica Peony Powder clinically and experimentally,the author searched and sorted out the related literature on Angelica Peony Powder and summarized studies on its clinical application,pharmacological action mechanism,and chemical composition.It is found that this prescription can not only treat chronic pelvic inflammation,ovarian cyst,dysmenorrhea,irregular menstruation,breast disease,pregnancy hypertension,infertility,perimenopausal syndrome,and other gynecological diseases but also has good clinical effects on non-alcoholic fatty liver disease,nephrotic syndrome,heart failure,cognitive impairment,chloasma,rheumatism,and other diseases,Whether combined with western medicine or used alone,the clinical effect is obviously better than that of western medicine treatment alone.In addition,it can largely correct the side effects of Western medicine.In terms of pharmacological action mechanism,after the literature review,it is found that Angelica Peony Powder has pharmacological effects such as anti-inflammation,regulating immunity,protecting vascular endothelium,protecting nerve cells,regulating endocrine,and regulating lipid metabolism.According to the summary,the current research on Angelica Peony Powder is more,but clinical reports of some related diseases are fewer.There are more studies on in vivo animal experiments and fewer studies on the cellular level.There is a lack of in-depth research on effective components and pharmacological action mechanisms and less combination with relevant research hotspots in recent years.All these need to be further studied and improved to provide a scientific basis for clinical and experimental research.
作者
任振杰
张业
梁帅
李栋梁
王晨阳
REN Zhenjie;ZHANG Ye;LIANG Shuai;LI Dongliang;WANG Chenyang(Zhongjing College,College of Traditional Chinese Medicine of Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;The Third Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450004,China)
出处
《世界中医药》
CAS
2023年第23期3465-3472,3477,共9页
World Chinese Medicine
基金
国家自然科学基金项目(81973739)
河南省重点研发与推广专项(科技攻关)项目(232102310459)
河南省研究生教育改革与质量提升工程项目课程思政示范课程(YJS2022SZ20)
河南省中医药科学研究专项课题(2021ZY2130,2022ZY1168)
河南省本科高校课程思政样板课程(方剂学)
河南省特色骨干学科中医学学科建设项目(STG-ZYX04-202138)。
关键词
当归芍药散
临床应用
药理作用
研究进展
妇科疾病
实验研究
药效成分
信号通路
Angelica Peony Powder
Clinical application
Pharmacological action
Research progress
Gynecological disease
Experiment research
Effective component
Signaling pathway
