摘要
目的 研究白细胞介素6(IL-6)、信号传导及转录激活因子3(STAT3)和细胞周期蛋白D1(Cyclin D1)在结直肠腺癌及癌旁组织中表达及其相关性,并分析其与患者临床病理特征及预后的相关性。方法 通过免疫组织化学法检测IL-6、STAT3和Cyclin D1在80例结直肠腺癌和癌旁组织中的表达水平,分析三者表达相关性及其与临床病理特征和预后的关系,并通过生物学数据库验证结果。结果 癌组织中IL-6、STAT3和Cyclin D1表达的阳性率分别为53.8%、63.8%、62.5%,癌旁组织中IL-6、STAT3和Cyclin D1的表达阳性率分别为32.5%、25.0%、15.0%(P<0.05)。癌组织中IL-6与STAT3的表达呈正相关(P<0.05);STAT3与Cyclin D1的表达呈正相关(P<0.05)。IL-6与CyclinD1的表达呈正相关(P<0.05)。STAT3与肿瘤的淋巴结转移及临床分期有关(P<0.05);Cyclin D1与肿瘤浸润深度、淋巴结转移及临床分期相关(P<0.05)。单因素分析显示,肿瘤分化程度、肿瘤浸润深度、淋巴结转移、临床分期、Cyclin D1是影响结直肠腺癌患者术后预后的危险因素;多因素分析表明,肿瘤分化程度、Cyclin D1是影响结直肠腺癌患者术后预后的独立危险因素(P<0.05)。结论 IL-6、STAT3和Cyclin D1在结直肠腺癌组织中过表达。Cyclin D1是结直肠腺癌术后预后的独立危险因素,可作为评估结直肠腺癌患者临床进展及预后的指标。
Objective To study the expression and correlation of interleukin 6(IL-6),signal transduction and activator of transcription 3(STAT3)and cyclin D1(Cyclin D1)in colorectal adenocarcinoma and adjacent tissues,and to analyze its relationship with clinical pathological characteristics and prognosis of patients.Methods The expression levels of IL-6,STAT3 and Cyclin D1 were detected by using immunohistochemical staining in 80 cases of colorectal adenocarcinoma and paracancerous tissues.The correlation of their expressions and their relationship with clinicopathological features and prognosis were analyzed and the results were verified by biological database.Results The positive expression rates of IL-6,STAT3 and Cyclin D1 expression in colorectal adenocarcinoma tissues were respectively 53.8%,63.8%,62.5%and the positive rates of IL-6,STAT3 and Cyclin D1 expression in adjacent tissues were respectively 32.5%,25%,15%(P<0.05).The expression of IL-6 and STAT3 in colorectal adenocarcinoma tissue was positively correlated(P<0.05),the expression of STAT3 and Cyclin D1 was positively correlated(P<0.05).STAT3 was related to lymph node metastasis and clinical stage(P<0.05),and Cyclin D1 was closely related to depth of invasion,lymph node metastasis and clinical stage(P<0.05).It showed that the degree of differentiation,depth of invasion,lymph node metastasis,clinical staging,Cyclin D1 were factors affecting the prognosis of patients with colorectal adenocarcinoma after surgery(P<0.05).It showed that the degree of differentiation and Cyclin D1 were independent risk factors for postoperative prognosis of colorectal adenocarcinoma patients(P<0.05).Conclusion IL-6,STAT3 and Cyclin D1 are overexpressed in colorectal adenocarcinoma.Cyclin D1 is an independent risk factor for postoperative prognosis of colorectal adenocarcinoma,and it can be used as an indicator to evaluate the clinical progress and prognosis of patients with colorectal adenocarcinoma.
作者
申东洋
赵帅
尚静
陶月佳
宋小萍
黄允宁
SHEN Dongyang;ZHAO Shuai;SHANG Jing;TAO Yuejia;SONG Xiaoping;HUANG Yunning(People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;Ningxia Medical University,Yinchuan 750004,China)
出处
《宁夏医学杂志》
CAS
2024年第1期1-5,I0001,共6页
Ningxia Medical Journal
基金
宁夏重点研发计划项目(2019BEG03007)
宁夏自然科学基金项目(2018AAC03270)。
