摘要
猪肺炎支原体是引起猪支原体肺炎的病原。由于缺乏成熟的猪肺炎支原体感染动物模型,使得猪肺炎支原体相关的抗感染免疫研究进展较为缓慢。本文从猪肺炎支原体感染后的炎症反应、固有免疫系统对猪肺炎支原体的识别、固有免疫细胞的作用、补体系统、抗菌肽、自噬以及细胞凋亡7个方面进行综述,旨在阐明固有免疫系统各组分在猪肺炎支原体感染中发挥的作用的研究进展,并对今后猪肺炎支原体感染的固有免疫应答研究的重点方向进行展望。
Mycoplasma hyopneumoniae is the pathogen causing swine mycoplasmal pneumonia.The lack of well-established animal models of M.hyopneumoniae infection has delayed the progress of M.hyopneumoniae-related anti-infection immunity studies.This paper reviews the inflammatory response,the recognition of M.hyopneumoniae by the innate immune system,and the role of innate immune cells,complement system,antimicrobial peptides,autophagy,and apoptosis in M.hyopneumoniae infection.The aim was to elucidate the important roles played by the components of the innate immune system in the control of M.hyopneumoniae infection,and prospect key research directions of innate immune response of M.hyopneumoniae infection in the future.
作者
赖加翠
何佳蔚
丁红雷
LAI Jiacui;HE Jiawei;DING Honglei(Laboratory of Veterinary Mycoplasmology,College of Veterinary Medicine,Southwest University,Chongqing 400715,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2023年第12期4773-4783,共11页
Chinese Journal of Biotechnology
基金
国家自然科学基金(32172870)
家畜疫病病原生物学国家重点实验室开放基金(SKLVEB2021KFKT003)。
关键词
猪肺炎支原体
固有免疫应答
炎症反应
Mycoplasma hyopneumoniae
innate immune response
inflammation
