摘要
目的:探讨中医治疗特发性肺纤维化(IPF)的辨证用药规律,为临床治疗IPF提供参考。方法:在中国知网、万方数据知识服务平台、PubMed、Embase等数据库中,检索建库至2021年8月8日辨证应用中药汤剂治疗IPF的相关文献,提取证型、症状及中药处方信息,构建IPF医案数据库,采用隐结构模型、频繁项集等数据挖掘方法分析中药汤剂内服治疗IPF的辨证用药规律。结果:共纳入文献39篇,包含病例1497例。纳入文献共包含症状163个,如咳嗽、乏力、气短等,将频次3的53个症状作为显变量构建IPF的隐结构模型,该模型提示气虚血瘀是IPF的常见证型。纳入文献包含的处方中共涉及中药163味,其中高频药物包括黄芪、甘草、丹参、当归、党参等;挖掘出“症状-中药”频繁项集5项,如“胸痛乏力+舌有瘀斑+脉沉细+丹参+桃仁+党参”;“证型-症状-中药”频繁项集4项,如“气虚血瘀+胸闷乏力+舌有瘀斑+黄芪+丹参+当归”。结论:气虚血瘀是IPF的临床常见证型,中药汤剂治疗IPF多以黄芪、甘草、丹参为主要药物,药物配伍根据临床辨证选择。
Objective:To explore medication regularity based syndrome differentiation in traditional Chinese medicine(TCM)treatment of idiopathic pulmonary fibrosis(IPF)and provide reference for clinical treat⁃ment of IPF.Methods:A literature search was con⁃ducted in databases such as CNKI,Wanfang,PubMed,Embase,etc.,for relevant articles on treating IPF with TCM medicinals decoctions up to August 8,2021.Information on syndromes,symptoms,and Chinese medicinals prescriptions was extracted to build an IPF medical case database.Data mining methods such as latent structure model and frequent item sets were used to analyze the medication regularity in internal treatment of IPF with Chinese medicinals decoctions.Results:A total of 39 articles were included,comprising 1497 cases.The included articles contained 163 symptoms,such as cough,fatigue,and dyspnea.A latent structure model of IPF was constructed using 53 symptoms with a frequency of 3 as significant variables,and the model suggested the syndrome of qi deficiency and blood stasis was a commonly seen syndrome in IPF.The prescriptions in the included articles involved 163 Chinese medicinals in which Huangqi(Astragali Radix),Gancao(Glycyrrhizae Radix et Rhizoma),Danshen(Salviae Miltiorrhizae Radix et Rhizoma),Danggui(Angelicae Sinensis Radix),Dangshen(Codonopsis Radix),etc.were with high frequency.Five“symptom-Chinese medicinal”frequent item sets were identified,such as“chest pain,fatigue+ecchymosis on tongue+deep and thready pulse+Danshen+Taoren(Persicae Semen)+Dangshen”.Four“syndrome-symptom-Chinese medicinal”frequent item sets were identified,such as“qi deficiency and blood stasis+chest tightness,fatigue+ecchymosis on tongue+Huangqi+Danshen+Danggui”.Conclusions:The syndrome of qi deficiency and blood stasis is a commonly seen syndrome in IPF.In treatment of IPF with Chinese medicinals decoctions,Huangqi,Gancao,Danshen were used as main medicinals,and the medicinals compatibility are chosen according to clinical syndrome differentiation.
作者
侯超峰
李亚兰
杜一杰
陈珂
陈乾
HOU Chaofeng;LI Yalan;DU Yijie;CHEN Ke;CHEN Qian(The Second Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450046,China;Medical College of Henan University of Chinese Medicine,Zhengzhou 450046,China;Intensive Care Unit of Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)
出处
《山东中医杂志》
2024年第2期133-138,152,共7页
Shandong Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:82104833)
河南中医药大学科技苗圃工程项目(编号:MP2020-12)。
关键词
特发性肺纤维化
数据挖掘
隐结构模型
频繁项集
辨证
用药规律
肺痿
idiopathic pulmonary fibrosis
data mining
latent structure model
frequent item sets
syndrome differentiation
medication regularity
lung flaccidity
