摘要
目的:探讨化痰通络汤治疗痰瘀阻络型卒中后认知障碍(post-stroke cognitive impairment,PSCI)患者的临床效果。方法:选取2022年4月—2023年3月就诊于福建中医药大学附属人民医院的60例痰瘀阻络型PSCI患者作为研究对象,按照简单随机分组将患者分为治疗组与对照组,各30例。两组均给予基础治疗,治疗组给予化痰通络汤联合尼莫地平治疗,对照组给予尼莫地平治疗,两组均持续治疗28 d。比较两组蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评分,中医症候积分,磁共振弥散张量成像(diffusion tensor imaging,DTI)各向异性分数(fractional anisotropy,FA)、轴向扩散系数(axial diffusivity,AD)、径向扩散系数(radial diffusivity,RD)及临床疗效。结果:治疗前,两组MoCA总分、视空间执行能力、注意力、延迟回忆、命名、定向评分、中医症候积分、FA、DR和AD比较,差异无统计学意义(P>0.05);治疗后,治疗组MoCA总分、视空间执行能力、注意力、延迟回忆、命名、定向评分及FA较治疗前升高,中医症候积分、DR和AD较治疗前下降,且治疗组改善优于对照组,差异有统计学意义(P<0.05)。治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:化痰通络汤能促进痰瘀阻络型PSCI患者白质纤维修复,增强视空间执行能力、注意力、延迟回忆、命名及定向力,改善认知功能障碍,提高总体认知功能水平。
Objective:To explore the clinical effect of Huatan Tongluo Decoction in the treatment of patients with post-stroke cognitive impairment(PSCI)of phlegm stasis obstructs collaterals.Method:From April 2022 to March 2023,A total of 60 patients with PSCI of phlegm stasis obstructs collaterals who admitted to the Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine were selected as the research objects,the patients were divided into the treatment group and the control group according to the simple random grouping,30 cases in each group.Two groups were given basic treatment,the treatment group was treated with Huatan Tongluo Decoction combined with Nimodipine,and the control group was treated with Nimodipine,two groups were treated continuously for 28 d.The Montreal cognitive assessment(MoCA)score,traditional Chinese medicine symptom score,magnetic resonance imaging diffusion tensor imaging(DTI)fractional anisotropy(FA),axial diffusivity(AD),radial diffusivity(RD)and clinical efficacy were compared between two groups.Result:Before treatment,there were no significant differences in total MoCA score,visuospatial execution ability,attention,delayed recall,name,orientation score,traditional Chinese medicine syndrome score,FA,DR and AD between two groups(P>0.05);after treatment,the total MoCA score,visuospatial execution ability,attention,delayed recall,name,orientation score and FA in two group were higher than those before treatment,while traditional Chinese medicine symptom score,DR and AD were lower than those before treatment,and the levels of improvement in the treatment group were better than those in the control group,the differences were statistically significant(P<0.05).The total effective rate in the treatment group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Huatan Tongluo Decoction can promote white matter fiber repair of patients with PSCI of phlegm stasis obstructs collaterals,improve cognitive dysfunction,enhance visual
作者
杨洋
陈甦
许成
梁晖
阮甦
严年文
陈巧兰
YANG Yang;CHEN Su;XU Cheng;LIANG Hui;RUAN Su;YAN Nianwen;CHEN Qiaolan(The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China;不详)
出处
《中外医学研究》
2023年第34期5-10,共6页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
福建省中医药科研项目(2021zylc36)。
关键词
化痰通络汤
卒中后认知功能障碍
痰瘀阻络型
磁共振弥散张量成像
Huatan Tongluo Decoction
Post-stroke cognitive impairment
Phlegm stasis obstructs collaterals
Magnetic resonance imaging diffusion tensor imaging
