摘要
目的分析妊娠期糖尿病孕妇血清维生素D水平与糖脂代谢、不良妊娠结局的相关性。方法选择2019年6月—2021年12月在福建省周宁县总医院进行定期产检且确诊为妊娠期糖尿病孕妇90例进行回顾性分析,根据其入组血清25-(OH)-VD水平不同分为25-(OH)-VD缺乏组(n=15)、25-(OH)-VD不足组(n=42)、25-(OH)-VD正常组(n=33),均进行空腹血糖、糖化血红蛋白、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等生化检测,并追踪记录其妊娠结局,比较各组检测结果及不良妊娠结局发生情况。结果25-(OH)-VD正常组的空腹血糖、糖化血红蛋白、三酰甘油、总胆固醇、低密度脂蛋白胆固醇水平明显低于25-(OH)-VD缺乏组、25-(OH)-VD不足组,高密度脂蛋白胆固醇水平明显高于25-(OH)-VD缺乏组、25-(OH)-VD不足组,差异有统计学意义(P<0.05)。经Pearson相关系数分析显示,血清25-(OH)-VD水平与空腹血糖、糖化血红蛋白、三酰甘油、总胆固醇、低密度脂蛋白胆固醇呈负相关,与高密度脂蛋白胆固醇水平呈正相关,差异有统计学意义(P<0.05)。25-(OH)-VD正常组妊娠期高血压、剖宫产、早产概率明显低于25-(OH)-VD缺乏组、25-(OH)-VD不足组,差异有统计学意义(P<0.05)。结论妊娠期糖尿病孕妇血清维生素D水平降低与糖脂代谢紊乱密切相关,且不良妊娠结局发生风险较高,故妊娠期糖尿病孕妇应监测血清维生素D水平针对性补充维生素D水平,降低不良妊娠结局发生风险。
Objective To analyze the correlation between serum vitamin D levels and glycolipid metabolism and ad-verse perinatal outcomes in pregnant women with gestational diabetes mellitus.Methods A retrospective analysis was performed on 90 pregnant women diagnosed with gestational diabetes who underwent regular antenatal check-up in Zhouning County General Hospital of Fujian Province from June 2019 to December 2021.They were divided into 25-(OH)-VD deficient group(n=15),25-(OH)-VD insufficiency group(n=42)and 25-(OH)-VD normal group(n=33)according to different serum 25-(OH)-VD levels.Fasting blood glucose,glycated hemoglobin,triacylglycerol,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol and other biochemical tests were performed in all groups,and their pregnancy outcomes were tracked and recorded,and the detection results and ad-verse perinatal outcomes of all groups were compared.Results The levels of fasting blood glucose,glycated hemoglo-bin,triacylglycerol,total cholesterol and low density lipoprotein cholesterol in 25-(OH)-VD normal group were sig-nificantly lower than those in 25-(OH)-VD deficient group and 25-(OH)-VD insufficiency group.The level of high density lipoprotein cholesterol was significantly higher than that of 25-(OH)-VD deficiency group and 25-(OH)-VD insufficiency group,the differences were statistically significant(P<0.05).Pearson correlation coefficient analysis showed that serum 25-(OH)-VD level was negatively correlated with fasting blood glucose,glycated hemoglobin,tria-cylglycerol,total cholesterol and low density lipoprotein cholesterol,and positively correlated with high density lipo-protein cholesterol,the differences were statistically significant(P<0.05).The rates of hypertension,cesarean section and preterm birth in 25-(OH)-VD normal group were significantly lower than those in 25-(OH)-VD deficiency group and 25-(OH)-VD insufficiency group,the differences were statistically significant(P<0.05).Conclusion The decrease of serum vitamin D level in
作者
汤进彬
TANG Jinbin(Department of Gynaecology and Obstetrics,Zhouning County General Hospital,Zhouning,Fujian Province,355400 China)
出处
《糖尿病新世界》
2023年第22期5-8,17,共5页
Diabetes New World Magazine
关键词
妊娠期糖尿病
血清维生素D
糖脂代谢
不良妊娠结局
Gestational diabetes mellitus
Serum vitamin D
Glycolipid metabolism
Adverse perinatal outcome
