摘要
目的分析外周血嗜酸粒细胞、中性粒细胞和鼻窦CT评分联合应用对慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)患者鼻内镜术后鼻息肉复发的评估价值。方法纳入确诊患者385例,2020年2月—2022年2月就诊,对符合纳入标准的病例行回顾性研究,由同一批医护人员行鼻内镜手术,将患者分成复发组(n=44)和未复发组(n=341),比较二组临床特征、外周血嗜酸粒细胞、中性粒细胞、免疫球蛋白E水平和鼻窦CT评分,经受试者工作特征曲线(receiver operating characteristic curves,ROC)评估指标联合和单独应用对术后鼻息肉复发的评估价值。结果复发组和未复发组患者性别、年龄、病程、吸烟、饮酒情况和既往病史比较差异无统计学意义(P>0.05),复发组中性粒细胞计数、免疫球蛋白E水平和鼻窦CT评分明显高于非复发组,组间比较差异有统计学意义(P<0.05);比较二组嗜酸性粒细胞水平,差异无统计学意义(P>0.05);指标联合评估鼻内镜术后鼻息肉复发的灵敏度为100.00%,特异度为97.73%,明显优于单项检测指标。结论外周血嗜酸粒细胞、中性粒细胞、免疫球蛋白E、鼻窦CT评分可用于预测鼻息肉鼻内镜术后鼻息肉复发,联合应用可进一步提高评估价值。
Objective To analyze the value of the combination of peripheral blood eosinophils,neutrophils and sinus CT score in evaluating the recurrence of nasal polyps in patients with chronic rhinosinusitis with nasal polyps(CRSwNP)after endoscopic sinus surgery.Methods A total of three hundred and eighty-five patients with confirmed diagnosis were enrolled in this retrospective study from February 2020 to February 2022.The patients were divided into recurrence group(n=44)and non-recurrence group(n=341)by the same group of medical staff.The clinical characteristics,peripheral blood eosinophils,neutrophils,immunoglobulin E levels and sinus CT scores of the two groups were compared.receiver operating characteristic curves(ROC)were used to evaluate the value of combined and single application of indicators in the evaluation of postoperative recurrence of nasal polyps.Results There was no significant difference in gender,age,course of disease,smoking,drinking and past medical history between the recurrence group and the non-recurrence group(P>0.05).The neutrophil count,immunoglobulin E level and sinus CT score in the recurrence group were significantly higher than those in the non-recurrence group,and there were significant differences between the two groups(P<0.05).There was no significant difference in eosinophil level between the two groups(P>0.05).The sensitivity and specificity of combined indicators in evaluating the recurrence of nasal polyps after endoscopic sinus surgery were 100.00%and 97.73%,which were significantly better than those of single detection indicators.Conclusion Peripheral blood eosinophils,neutrophils,immunoglobulin E and sinus CT score can be used to predict the recurrence of nasal polyps after endoscopic sinus surgery.Combined application can further improve the evaluation value and can be popularized.
作者
王保成
李海春
裴雪艳
李扬
王岚
胡艳红
WANG Baocheng;LI Haichun;PEI Xueyan;LI Yang;WANG Lan;HU Yanhong(Depatment of Otolaryngology,Head and Neck Surgery,Affiliated Hospital of Tangshan Vocational and Techical College,Tangshan 063000,China)
出处
《中国煤炭工业医学杂志》
2023年第6期649-653,共5页
Chinese Journal of Coal Industry Medicine
基金
河北省健康委员会2024年医学科技计划项目(编号:20241828)。
